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FLASH GENE
Symbol MAGEA5 contributors: mct - updated : 20-05-2020
HGNC name melanoma antigen family A, 5
HGNC id 6803
Location Xq28      Physical location : 151.282.528 - 151.286.444
Synonym name
  • cancer/testis antigen family 1, member 5
  • Synonym symbol(s) MAGE5, MAG5, CT1.5, MAGEA4, MGC129526
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 3.89 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1664 - 124 - 2012 22869527
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    cell lineage
    cell lines many tumors cell lineages (melanoma, lung, breast)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    intraspecies homolog to MAGEA6/MAGEA4
    Homologene
    FAMILY MAGE family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in tumor transformation or progression
  • testis proteins, FMR1NB, NXF2, MAGEA5, FSIP1, and STARD6, are required for accurate chromosome segregation in tumor cells
  • MAGEA1, MAGEA2, MAGEA3, MAGEA5, MAGEA8 genes are crucial in maintaining normal testicular size and protecting germ cells from excessive apoptosis under genotoxic stress
  • MAGEA5, MAGEA8, MAGEB4 and MAGEB6 may have roles as tumor suppressors in the occurrence and development of breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • notable correlation between MAGEA5 and MAGEA11 and lower efficacy of EGFR tyrosine kinase inhibitors (TKI) in Head and Neck Cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS