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FLASH GENE
Symbol MAGEA3 contributors: mct/npt - updated : 08-12-2009
HGNC name melanoma antigen family A, 3
HGNC id 6801
Location Xq28      Physical location : 151.934.652 - 151.938.240
Synonym name
  • protein recognized by autologous cytotoxic T lymphocytes
  • MAGE-3 antigen
  • cancer/testis antigen family 1, member 3
  • Synonym symbol(s) MAGE3, HIP8, HYPD, MGC14613, MAGEA6, CT1.3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with other family A members
    STRUCTURE 3.06 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    GABRQ Xq28 gamma-aminobutyric acid (GABA) receptor, theta TRAG3 Xq28 taxol resistance associated gene 3 MAGEA2b Xq28 melanoma antigen, family A, 2, copy b MAGEA12 Xq28 melanoma antigen, family A, 12 CSAGE Xq28 chondrosarcoma associated gene 1 MAGEA2 Xq28 melanoma antigen, family A, 2 LOC389903 X similar to Taxol resistant associated protein 3 (TRAG-3) MAGEA3 Xq28 melanoma antigen, family A, 3 MAGEA6 Xq28 melanoma antigen, family A, 6 psMAGEA Xq28 melanoma antigen pseudogene, family A CETN2 Xq28 centrin, EF-hand protein, 2 H105E3 Xq28 centrin, EF-hand protein, 2 ZNF185 Xq28 zinc finger protein 185 (LIM domain) PNMA5 Xq28 paraneoplastic antigen like 5 PNMA3 Xq28 paraneoplastic antigen MA3 MGC15827 Xq28 hypothetical protein MGC15827 MAGEA1 Xq28 melanoma antigen, family A, 1 (directs expression of antigen MZ2-E)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1753 - 314 - Yang (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineadrenal gland   moderately
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland moderately
     female systemplacenta  highly
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines myeloma cell lines, melanoma, head and neck squamous cell carcinoma, lung, breast carcinoma
    fluid/secretion lymph
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    interspecies homolog to C.elegans Y37E3.15
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in embryonal development and tumor transformation or aspects of tumor progression
  • acting as a tumor antigen
  • functional integrator of diverse signals, including FGFR2 and fibronectin, to modulate cancer progression (Liu 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense
    text
  • recognized on a melanoma by autologous cytolytic T
  • lymphocytes
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein target of the breast cancer risk factor fibroblast growth factor receptor 2 (FGFR2) (Liu 2008)
    cell & other
    REGULATION
    activated by MBD2 (up-regulate the basal activity of the promoter of MAGE proteins) (Wischniewski 2007)
    inhibited by FGFR2 (negatively regulated by FGFR2) (Zhu 2008)
    repressed by the TRD of MBD1 and MECP2 (Wischnewski 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, melanoma, advanced gastric carcinomas and hepatocellular carcinomas, squamous cell carcinoma of head and neck, malignant myeloma
    constitutional     --low  
    results in Tp53 transcriptional induction, also through reciprocal histone acetylation and methylation modifications (Zhu 2008)
    tumoral     --over  
    by promoter hypomethylation up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of colorectal carcinomas (Kim 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene aberrant methylation patterns of MAGEs CpG islands using methylation-special PCRs may be useful for diagnosis of hepatocellular carcinoma
    Marker
    Therapy target
    ANIMAL & CELL MODELS