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FLASH GENE
Symbol MAGEA2 contributors: mct/npt - updated : 25-09-2009
HGNC name melanoma antigen family A, 2
HGNC id 6800
Location Xq28      Physical location : 151.883.118 - 151.922.364
Synonym name
  • cancer/testis antigen family 1, member 2
  • MAGE-2 antigen
  • Synonym symbol(s) MAGE2, MAGEA2A, MGC131923, CT1.2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, overlapping
    STRUCTURE 3.98 kb     4 Exon(s)    2 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure
  • having two identical copies at different loci
  • having consensus binding sequences for MYB, ETS1, PUF, AP2 and ATF transcription factors
  • MAPPING cloned Y linked N status tentative : very preliminary evidence
    Physical map
    GABRQ Xq28 gamma-aminobutyric acid (GABA) receptor, theta TRAG3 Xq28 taxol resistance associated gene 3 MAGEA2b Xq28 melanoma antigen, family A, 2, copy b MAGEA12 Xq28 melanoma antigen, family A, 12 CSAGE Xq28 chondrosarcoma associated gene 1 MAGEA2 Xq28 melanoma antigen, family A, 2 LOC389903 X similar to Taxol resistant associated protein 3 (TRAG-3) MAGEA3 Xq28 melanoma antigen, family A, 3 MAGEA6 Xq28 melanoma antigen, family A, 6 psMAGEA Xq28 melanoma antigen pseudogene, family A CETN2 Xq28 centrin, EF-hand protein, 2 H105E3 Xq28 centrin, EF-hand protein, 2 ZNF185 Xq28 zinc finger protein 185 (LIM domain) PNMA5 Xq28 paraneoplastic antigen like 5 PNMA3 Xq28 paraneoplastic antigen MA3 MGC15827 Xq28 hypothetical protein MGC15827 MAGEA1 Xq28 melanoma antigen, family A, 1 (directs expression of antigen MZ2-E)
    RNA
    TRANSCRIPTS type messenger
    text three variants encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1979 - 314 - Wischnewski (2007)
  • differing from variants 2 and 3 in the 5' UTR
  • 6 - 1965 - 314 - Wischnewski (2007)
    having an alternate segment in the 5' UTR as compared to variant 1
    6 - 1981 - 314 - Wischnewski (2007)
  • having an alternate segment and an additional segment in the 5' UTR as compared to variant 1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines a variety of cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in embryonal development and tumor transformation or aspects of tumor progression
  • confers wild-type-TP53-sensitive resistance to etoposide (ET) by inducing a novel TP53 inhibitory loop involving recruitment of histone deacetylase 3 (HDAC3) to MAGEA2/TP53 complex (Monte 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense
    text recognized on a melanoma by autologous cytolytic T lymphocytes
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by MBD2 (up-regulate the basal activity of the promoter of MAGE proteins) (Wischniewski 2007)
    repressed by the TRD of MBD1 and MECP2 (Wischnewski 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS