Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol MAGEA11 contributors: mct - updated : 15-05-2014
HGNC name melanoma antigen family A, 11
HGNC id 6798
Location Xq28      Physical location : 148.769.902 - 148.798.926
Synonym name
  • cancer/testis antigen 1.11
  • MAGE-11 antigen
  • Synonym symbol(s) MAGE11, MAGB, MAGE-11, MAGEA-11, MGC10511, CT1.11
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 29.03 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FMR1 Xq27.3 fragile X mental retardation 1 FLJ25736 LOC286397 Xq28 similar to Ferritin heavy chain (Ferritin H subunit) LOC389899 X similar to HS1 binding protein LOC347509 Xq28 similar to ribosomal protein L7-like 1 FMR2 Xq28 fragile X mental retardation 2 IDS Xq27.3-q28 iduronate 2-sulfatase (Hunter syndrome) IDSP1 Xq28 iduronate 2-sulfatase pseudogene 1 LOC91966 Xq28 hypothetical protein LOC91966 LOC347512 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LW-1 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) FAM11A Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LOC392556 X similar to Melanoma-associated antigen 11 (MAGE-11 antigen) MAGEA11 Xq28 melanoma antigen, family A, 11 MAGEA9 Xq28 melanoma antigen, family A, 9 MAGEA7 Xq28 melanoma antigen, family A, 7, pseudogene MAGEA8 Xq28 melanoma antigen, family A, 8 LOC389900 X similar to DKFZP586L0724 protein LOC389901 X similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) CXorf6 Xq28 chromosome X open reading frame 6 MTM1 Xq28 myotubular myopathy 1 MTMR1 Xq28 myotubularin related protein 1 CD99L2 Xq28 CD99 antigen-like 2 HMGB3 Xq28 high-mobility group box 3 LOC392557 X similar to hypothetical protein GPR50 Xq28 G protein-coupled receptor 50 LOC286456 Xq28 similar to NGFI-A binding protein 1; NGFI-A-binding protein 1; EGR1 binding protein 1 LOC139135 Xq28 hypothetical protein LOC139135 TMG3 Xq28 transmembrane gamma-carboxyglutamic acid protein 3 FATE Xq28 transmembrane gamma-carboxyglutamic acid protein 3 LOC389902 X similar to Cyclic-nucleotide-gated olfactory channel (Cyclic-nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2) (Aorta CNG channel) (RACNG)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 1892 48 429 - 1998 9495246
  • 5 exons : exon 3, 4, 5, 6, 7
  • 5 splicing 1893 44 400 - 1998 9495246
  • 5 exons : exon 1, 2, 5, 6, 7
  • differing in the 5' UTR and CDS compared to variant 1
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousnerve   moderately
    Reproductivefemale systemplacenta  highly
     female systemuterus  moderately
     male systemtestis   
    Skin/Tegumentskin   moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines many tumor cell lines (melanoma, head and neck squamous cell carcinoma)
    at STAGE
    physiological period pregnancy
    Text placenta
  • a MAGE domain
  • a MXXIF motif (185)MXXIF(189), involved in interaction with the N-terminal region of EP300
    interspecies homolog to murine Magea8
    intraspecies homolog to MAGEA10/MAGEA9
    FAMILY MAGE family
    CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • may play a role in embryonal development and tumor transformation or aspect of tumor progression
  • being a unique androgen receptor coregulator that increases androgen receptor activity by modulating the androgen receptor interdomain interaction
  • coregulator function of MAGEA11 extends to isoform-specific regulation of PGR during the cyclic development of the human endometrium
  • mediates the stimulatory effects of cyclic AMP on androgen receptor (AR) transcriptional activity in prostate cancer
  • is required for normal AR function during human male fetal development
  • is potentially a proto-oncogene whose increased expression in prostate cancer reverses RBL1 from a transcriptional repressor to a transcriptional activator of the androgen receptor and E2F1
    PHYSIOLOGICAL PROCESS immunity/defense
    text tumor antigen
    a component
    small molecule
  • androgen receptor NH(2)-terminal FXXLF motif (alpha-helical region)
  • is an AR coregulator that specifically binds the AR NH(2)-terminal FXXLF motif and modulates the AR NH(2)- and carboxyl-terminal N/C interaction to increase AR transcriptional activity
  • MAGEA11 links N-terminal domains of AR and EP300 to promote transcriptional synergy through a cadre of FXXLF-related interacting motifs
  • coregulator effects of MAGEA11 on the AR N and C-terminal interaction amplify the androgen-dependent transcriptional response to EP300 required for normal human male sex development in utero
  • increases AR transcriptional activity by forming a molecular bridge between transcriptionally active AR dimers
  • interacts with the AR N-terminal FXXLF motif, increases AR-(1660) activity directly, and increases the activity of wild-type AR in the absence or presence of androgen
  • MAGEA11 interaction with RBL1 was associated with transcriptional repression in cells with low MAGEA11 and transcriptional activation in cells with higher MAGEA11
  • cell & other
    Other DNA methylation regulates nucleosome occupancy at MAGEA11, and this appears to function cooperatively with sequence-specific transcription factors to regulate gene expression
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate and epithelial ovarian cancers (EOC), associated with promoter and global DNA hypomethylation
    Variant & Polymorphism
    Candidate gene
    Therapy target
    new target for prostate cancer treatment