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FLASH GENE
Symbol MAGEA11 contributors: mct - updated : 15-05-2015
HGNC name melanoma antigen family A, 11
HGNC id 6798
Location Xq28      Physical location : 148.769.902 - 148.798.926
Synonym name
  • cancer/testis antigen 1.11
  • MAGE-11 antigen
  • Synonym symbol(s) MAGE11, MAGB, MAGE-11, MAGEA-11, MGC10511, CT1.11
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 29.03 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 1892 48 429 - 1998 9495246
  • 5 exons : exon 3, 4, 5, 6, 7
  • 5 splicing 1893 44 400 - 1998 9495246
  • 5 exons : exon 1, 2, 5, 6, 7
  • differing in the 5' UTR and CDS compared to variant 1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousnerve   moderately
    Reproductivefemale systemplacenta  highly
     female systemuterus  moderately
     male systemtestis   
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines many tumor cell lines (melanoma, head and neck squamous cell carcinoma)
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • a MXXIF motif (185)MXXIF(189), involved in interaction with the N-terminal region of EP300
  • HOMOLOGY
    interspecies homolog to murine Magea8
    intraspecies homolog to MAGEA10/MAGEA9
    Homologene
    FAMILY MAGE family
    CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may play a role in embryonal development and tumor transformation or aspect of tumor progression
  • being a unique androgen receptor coregulator that increases androgen receptor activity by modulating the androgen receptor interdomain interaction
  • coregulator function of MAGEA11 extends to isoform-specific regulation of PGR during the cyclic development of the human endometrium
  • mediates the stimulatory effects of cyclic AMP on androgen receptor (AR) transcriptional activity in prostate cancer
  • is required for normal AR function during human male fetal development
  • is potentially a proto-oncogene whose increased expression in prostate cancer reverses RBL1 from a transcriptional repressor to a transcriptional activator of the androgen receptor and E2F1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text tumor antigen
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • androgen receptor NH(2)-terminal FXXLF motif (alpha-helical region)
  • is an AR coregulator that specifically binds the AR NH(2)-terminal FXXLF motif and modulates the AR NH(2)- and carboxyl-terminal N/C interaction to increase AR transcriptional activity
  • MAGEA11 links N-terminal domains of AR and EP300 to promote transcriptional synergy through a cadre of FXXLF-related interacting motifs
  • coregulator effects of MAGEA11 on the AR N and C-terminal interaction amplify the androgen-dependent transcriptional response to EP300 required for normal human male sex development in utero
  • increases AR transcriptional activity by forming a molecular bridge between transcriptionally active AR dimers
  • interacts with the AR N-terminal FXXLF motif, increases AR-(1660) activity directly, and increases the activity of wild-type AR in the absence or presence of androgen
  • MAGEA11 interaction with RBL1 was associated with transcriptional repression in cells with low MAGEA11 and transcriptional activation in cells with higher MAGEA11
  • notable correlation between MAGEA5 and MAGEA11 and lower efficacy of EGFR tyrosine kinase inhibitors (TKI) in Head and Neck Cancer
  • cell & other
    REGULATION
    Other DNA methylation regulates nucleosome occupancy at MAGEA11, and this appears to function cooperatively with sequence-specific transcription factors to regulate gene expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate and epithelial ovarian cancers (EOC), associated with promoter and global DNA hypomethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    new target for prostate cancer treatment
    ANIMAL & CELL MODELS