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FLASH GENE

Symbol

MAG

contributors: mct - updated : 22-05-2017

HGNC name	myelin associated glycoprotein
HGNC id	6783

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PMLD4 Pelizaeus-Merzbacher-like disease 4 SPG75 spastic paraplegia 75, autosomal recessive
Location	19q13.12      Physical location : 35.783.037 - 35.804.707
Synonym name	sialic acid-binding immunoglobulin-like lectin 4A
Synonym symbol(s)	GMA, SIGLEC4, S-MAG, SIGLEC-4A, SIGLEC4A

DNA

TYPE	functioning gene
STRUCTURE	21.67 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002361 11 - 2380 69.1 626 - 2008 18941509 lacking exon 11, stop codon in exon 12 NM_080600 12 splicing 2425 64.2 583 - 2008 18941509 stop codon contained in exon 11 NM_001199216 - - 2445 - 601 - 2008 18941509

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Nervous brain       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central white matter     Homo sapiens Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous oligodendrocyte Nervous Purkinje cell Nervous Schwann cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

Text	in Schwann cells prior to the onset of myelination

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

five extracellular Ig-like domains (four of the C2, one of the V type)

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

interspecies

homolog to murine Mag

Homologene

FAMILY

sialoadhesin family, Ig superfamily

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	type 1 membrane protein

basic FUNCTION	cell adhesion molecule for postnatal neural development
	inhibitor of axon extension (neurite outgrow)
	RTN4 and MAG are differently involved in oligodendrocyte maturation , suggesting that RTN4 may influence also remyelination in pathological conditions such as multiple sclerosis
	detected in Schwann cells prior to the onset of myelination, suggesting its functions in the initiation of myelination
	MAG, located in the adaxonal plasmalemma of myelin-producing cells, is known to signal to the axon and to modulate axonal caliber through phosphorylation of axonal neurofilament proteins
	physiological roles of RTN4, MAG, OMG in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration
	engages membrane-domain resident neuronal receptors to protect neurons from excitotoxicity, and soluble MAG mitigates excitotoxic damage
	MAG together with other adhesion molecules such as CADM4 is important in sustaining axonal integrity
	involved in myelin maintenance and glia-axon interaction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to sialylated glycoconjugates mediating myelin cell-cell interaction
	interaction with RTN4R (ligand of RTN4R that limit axonal regeneration after CNS injury)
	MAG binds to LRP1 with high affinity but failed to induce phosphorylation of NTRK1 or ERK1/2
	ADGRV1 inhibits the ubiquitylation of MAG, thus enhancing the stability of this protein, and the calcium-binding domains of ADGRV1 are essential for this regulation

cell & other

REGULATION

Other

RNF10 regulates MAG expression and is required for myelin formation

ASSOCIATED DISORDERS

corresponding disease(s)

SPG75 , PMLD4

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology acquired   importance of early, effective anti-B-cell treatments for preventing progression of the anti-myelin-associated glycoprotein polyneuropathy

ANIMAL & CELL MODELS

Mag-null mice displayed markedly increased seizure activity in response to intraperitoneal injection of kainic acid, an excitotoxic glutamate receptor agonist