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FLASH GENE
Symbol MAFG contributors: mct/npt - updated : 04-10-2016
HGNC name v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
HGNC id 6781
Location 17q25.3      Physical location : 79.876.146 - 79.885.588
Synonym name
  • basic leucine zipper transcription factor MAFG
  • v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein G
  • transcription factor MafG
  • Synonym symbol(s) ADAPT66, MGC13090, MGC20149, hMAF
    DNA
    TYPE functioning gene
    STRUCTURE 9.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    OCSP 17q25.3 oculospanin PDE6G 17q21.1 phosphodiesterase 6G, cGMP-specific, rod, gamma LOC339229 17q25.3 hypothetical protein LOC339229 MGC16597 17q25.3 similar to RIKEN cDNA 3110023B02 LOC339231 17q25.3 hypothetical protein LOC339231 HGS 17q25 hepatocyte growth factor-regulated tyrosine kinase substrate MRPL12 17q25 mitochondrial ribosomal protein L12 SLC25A10 17q25.3 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 LOC388432 17 similar to dysferlin-interacting protein 1 P4HB 17q25.2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55) ARHGDIA 17q25.3 Rho GDP dissociation inhibitor (GDI) alpha THOC4 17q25.3 THO complex 4 ANAPC11 17q25.3 APC11 anaphase promoting complex subunit 11 homolog (yeast) NPB 17q25.3 preproneuropeptide B LOC388433 17 LOC388433 PCYT2 17q25.3 phosphate cytidylyltransferase 2, ethanolamine SIRT7 17q25 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) MGC13090 17q25.3 hypothetical protein MGC13090 MAFG 17q25 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) LOC92659 17q25.3 hypothetical protein BC009233 PYCR1 17q25.3 pyrroline-5-carboxylate reductase 1 LOC255275 17q25.3 similar to myeloid-associated differentiation marker LOC147111 17q25.3 hypothetical protein LOC147111 ASPSCR1 17q25 alveolar soft part sarcoma chromosome region, candidate 1 STRA13 17q25.3 stimulated by retinoic acid 13 MGC20806 17q25.3 hypothetical protein MGC20806 RAC3 10q25.3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) DCXR 17q25.3 dicarbonyl/L-xylulose reductase GPS1 17q25.3 G protein pathway suppressor 1 PP3111 17q25.3 PP3111 protein
    RNA
    TRANSCRIPTS type messenger
    text variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5043 17 162 - Yamamoto (2006)
    - - 5038 17 162 - Yamamoto (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineparathyroid   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a basic region-leucine zipper motif through which they form homodimers or heterodimers with SLC8A1 and ACOT7 proteins
  • MAFG C terminus is required for NFE2 function, suggesting that efficient targeting of NFE2 to a specific nuclear scaffold is important to achieve high-level activity
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to avian musculoaponeurotic fibrosarcoma (v-maf) oncogene
    intraspecies homolog to mafk
    Homologene
    FAMILY
  • bZIP transcription factors family
  • Maf subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional activator by dimerzing with other basic zipper proteins
  • regulate expression and induction of detoxifying enzyme genes including quinone oxidoreductase
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAFG is required only for NFE2 binding to Maf recognition element (MARE) and to facilitate NFE2-mediated transcriptional activation
  • cell & other
    REGULATION
    induced by stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS