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FLASH GENE
Symbol MAF1 contributors: mct/ - updated : 22-01-2011
HGNC name MAF1 homolog (S. cerevisiae)
HGNC id 24966
Location 8q24.3      Physical location : 145.159.304 - 145.162.515
Synonym name
  • homolog of yeast MAF1
  • repressor of RNA polymerase III transcription MAF1 homolog
    • Synonym symbol(s) DKFZp586G1123, MGC31779, MGC20332, MGC39758
    DNA
    TYPE functioning gene
    STRUCTURE 3.21 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1828 - 256 - 2002 12504022
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two domains conserved during evolution, resistant to mild proteolysis
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast Maf1
    Homologene
    FAMILY
  • MAF1 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • constitutively nuclear but its nucleolar localization is inhibited by MTOR, indicating that MTOR regulates nucleoplasm-to-nucleolus transport of MAF1
    • basic FUNCTION
  • putative repressor of RNA polymerase (pol) III transcription, involved in the regulation of transcription, DNA-dependent
  • involved in coupling carbon metabolism to RNA polymerase III transcription
  • MED20 and MAF1 function in parallel pathways to negatively regulate ribosomal protein mRNA and tRNA synthesis
  • repressor that binds and inhibits pol III, and is phosphorylated in a MTOR-dependent manner both
  • major regulator of pol III and POLR1D transcription in human cells)
  • rapidly represses Pol III transcription
  • specifically represses transcription initiation from Pol III promoters and also prevents reinitiation by binding Pol III during transcription elongation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of MTOR with MAF1 and GTF3C1 in nuclei
    • cell & other
    REGULATION
    Other directly and efficiently phosphorylated by MTOR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS