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FLASH GENE
Symbol MACROD1 contributors: mct/npt - updated : 08-07-2009
HGNC name MACRO domain containing 1
HGNC id 29598
Location 11q13.1      Physical location : 63.766.030 - 63.933.585
Synonym name
  • leukemia related protein 16
  • protein LRP16
    • Synonym symbol(s) LRP16
    DNA
    TYPE functioning gene
    STRUCTURE 167.55 kb     11 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor   HRE
    text structure ESR1 and Sp1 play a role in activation of the gene promoter (Zhao 2005)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1277 - 325 - Yang (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Urinarykidney   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • only a stand-alone macro domain functional module that can
    • serve as the AR coactivator (Yang 2009)
    HOMOLOGY
    Homologene
    FAMILY
  • macro domain superfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • cooperates with the estrogen receptor alpha and enhances the receptor transcriptional activity in an estrogen-dependent manner (Yang 2009)
  • plays an essential role in AR transactivation (Yang 2009)
  • may be involved in estrogen signaling (Han 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to androgen receptor (AR) via its macro domain and amplifies the transactivation function of AR in response to androgen (Yang 2009)
  • physically interacts with ERalpha (ESRT1) in a manner that is estrogen independent but is enhanced by estrogen (Han 2007)
    • cell & other
    REGULATION
    Other estrogenically regulated and it can stimulate the proliferation of MCF-7 breast cancer cells (Han 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RUNX1 (RUNX1 fusion partner of LRP16 on 11q13 involving t(11;21)(q13;q22) in monocytic leukemia (Imagama (2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS