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FLASH GENE
Symbol MACC1 contributors: mct/npt - updated : 11-03-2009
HGNC name metastasis associated in colon cancer 1
HGNC id 30215
Location 7p21.1      Physical location : 20.174.287 - 20.257.013
Synonym name putative binding protein 7a5
Synonym symbol(s) 7A5, SH3BP4L
DNA
TYPE functioning gene
STRUCTURE 82.74 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 9167 96.51 852 - Stein (2009)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 liver    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an SH3 domain, together with the proline-rich consensus sequence for binding to class I SH3 domain–containing proteins (R/KXXPXXP)
  • additional motifs potentially recognized by noncanonical class I SH3 domains
  • binding motifs for proteins with SH2 domains
  • Eps15 homology domains
  • clathrin and retinoblastoma protein interaction domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • in tumor specimens is an independent prognostic indicator of metastasis formation and metastasis-free survival (Stein 2009)
  • may be promoting proliferation, invasion and hepatocyte growth factor -induced scattering of colon cancer cells (Stein 2009)
  • regulates cascade hepatocyte growth factor (HGF)/HGF receptor (MET) signaling pathway, associated with both malignant transformation and metastatic potential of colorectal cancer (Boardman 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MET transcriptional target of MACC1 (Stein 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon cancer cells (tumors with metachronous metastasis expressed significantly higher MACC1 mRNA leve) (Stein 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene useful for the identification of poor prognosis subjects with colorectal cancer (Stein 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS