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FLASH GENE

Symbol

MACC1

contributors: mct/npt - updated : 11-03-2009

HGNC name	metastasis associated in colon cancer 1
HGNC id	30215

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p21.1      Physical location : 20.174.287 - 20.257.013
Synonym name	putative binding protein 7a5
Synonym symbol(s)	7A5, SH3BP4L

DNA

TYPE	functioning gene
STRUCTURE	82.74 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 7 - 9167 isoform 1 96.51 852 - Stein (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       liver

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an SH3 domain, together with the proline-rich consensus sequence for binding to class I SH3 domain–containing proteins (R/KXXPXXP)
	additional motifs potentially recognized by noncanonical class I SH3 domains
	binding motifs for proteins with SH2 domains
	Eps15 homology domains
	clathrin and retinoblastoma protein interaction domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	in tumor specimens is an independent prognostic indicator of metastasis formation and metastasis-free survival (Stein 2009)
	may be promoting proliferation, invasion and hepatocyte growth factor -induced scattering of colon cancer cells (Stein 2009)
	regulates cascade hepatocyte growth factor (HGF)/HGF receptor (MET) signaling pathway, associated with both malignant transformation and metastatic potential of colorectal cancer (Boardman 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

MET transcriptional target of MACC1 (Stein 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colon cancer cells (tumors with metachronous metastasis expressed significantly higher MACC1 mRNA leve) (Stein 2009)

Susceptibility

Variant & Polymorphism

Candidate gene	useful for the identification of poor prognosis subjects with colorectal cancer (Stein 2009)
Marker
Therapy target

ANIMAL & CELL MODELS