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FLASH GENE
Symbol LZTS3 contributors: npt/mct - updated : 26-10-2018
HGNC name leucine zipper tumor suppressor family member 3
HGNC id 30139
Location 20p13      Physical location : -
Genatlas name ProSAPiP1 protein
Synonym name
  • proline rich synapse associated protein interacting protein 1
  • uncharacterized protein KIAA0552
  • proSAP-interacting protein 1
  • Synonym symbol(s) KIAA0552, ProSAPiP1
    DNA
    TYPE functioning gene
    STRUCTURE 10.98 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4196 71 673 - 2006 16522626
    6 - 4118 - 627 - 2006 16522626
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex lowly
     brain   predominantly Homo sapiens
     nervecranial nerveoptic nerve lowly
    Urinarykidney   predominantly Homo sapiens
    Visualeyeretinafovea lowly
     eyeretinamacula lowly
     eyelens  lowly
     eyeanterior segment  lowly
     eyeuveachoroid lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryolfactory  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique PDZ domain
  • HOMOLOGY
    interspecies homolog to murine Prosapip1
    homolog to rattus Prosapip1
    intraspecies homolog to human KIAA0341
    homolog to significant sequence homology with the PSD protein LZTS1
    Homologene
    FAMILY
  • ProSAPs/Shanks family
  • leucine zipper tumor suppressor (LZTS) protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text co-localizes with ProSAP2/Shank3 in excitatory spines and synapses
    basic FUNCTION
  • have a major scaffolding function for components of the postsynaptic density (PSD) of excitatory brain synapses
  • is indeed involved in promoting the maturation of dendritic spines—most probably via regulating SPAR levels at the PSD
  • fulfill specific molecular functions at the PSD to guarantee the proper maturation of excitatory spine synapses
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text cell growth and/or maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind and recruit SIPA1L1 to synapses with a central coiled-coil region that harbors a leucine zipper motif
  • interaction partner of the well-known PSD protein SHANK3 and SPAR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS