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FLASH GENE
Symbol LZTS2 contributors: mct/npt/pgu/shn - updated : 08-12-2012
HGNC name leucine zipper, putative tumor suppressor 2
HGNC id 29381
Location 10q24.31      Physical location : 102.756.964 - 102.767.585
Synonym name
  • LZTS1-related gene
  • protein LAPSER1
  • leucine zipper putative tumor suppressor 2
  • Synonym symbol(s) LAPSER1, KIAA1813, RP11-108L7.8
    DNA
    TYPE functioning gene
    STRUCTURE 10.73 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D10S192 - D10S1265 - LZTS2 - D10S1710 - D10S1240 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2858 - 669 - 2008 18490357
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate  highly Homo sapiensNM_032429
     male systemtestis  highly Homo sapiensNM_032429
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • P-box domain
  • Q-rich domain
  • multiple leucine zippers
  • C terminal domain inhibiting katanin-mediated microtubule
  • functional nuclear export signal (NES)in the C terminus
  • HOMOLOGY
    interspecies ortholog to Lzts2, Mus musculus
    ortholog to Lzts2, Rattus norvegicus
    ortholog to LZTS2, Pan troglodytes
    Homologene
    FAMILY
  • leucine zipper putative tumor suppressor
  • CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • colocalizes to the centrosomes and midbodies in mitotic cells with gamma-tubulin, MKLP1, and p80 katanin
  • centrosomal localization independent of microtubules and was preferential to mother centrioles
  • basic FUNCTION
  • acting as a negative regulation of cell cycle
  • involved in the regulation of cell growth whose loss of function contribute to the development of cancer
  • alters cell proliferation by regulating cytokinesis
  • pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing
  • participates in cytokinesis by interacting with KATNB1, the disruption of which may potentially cause genetic instability and cancer
  • may be involved in the control of cell migration via the regulation of microtubule release from the centrosomes
  • beta-catenin-interacting protein that can modulate beta-catenin signaling and localization
  • putative cytokinetic tumor suppressor that binds directly to SHANK3 and is a novel postsynaptic density component
  • functions as a novel CTNNB-interacting protein and represses CTNNB-mediated transcription on T-cell factor/lymphoid enhancing factor
  • a critical role in renal development and is a critical regulator of CTNNB-mediated nephrogenesis
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CTNNB (
  • p80 katanin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    induces abortive cytokinesis, followed by mitotic catastrophe in a p80 katanin-dependent manner
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lzts2 KO mice exhibit severe kidney and urinary tract developmental defects, including renal/ureteral duplication, hydroureter, and hydronephrosis
  • alteration of CTNNB subcellular localization in fibroblasts from Lzts2 null embryos