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FLASH GENE
Symbol LZTS1 contributors: mct/npt - updated : 08/10/2008
HGNC name leucine zipper, putative tumor suppressor 1
HGNC id 13861
Location 8p22      Physical location : 20.103.676 - 20.112.803
Synonym name
  • F37/Esophageal cancer-related gene-coding leucine-zipper motif
  • PSD-Zip70
    • Synonym symbol(s) FEZ1, F37, Psdzip70
    DNA
    TYPE functioning gene
    STRUCTURE 9.13 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5459 66.5 596 - Ishii (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Endocrineneuroendocrinepituitary  highly
    Nervousnerve   highly
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine-zipper region
    • HOMOLOGY
    Homologene
    FAMILY
  • leucine-zipper protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • inhibits cancer cell growth through regulation of mitosis, and its alterations result in abnormal cell growth
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other hyperphosphorylated by cAMP-dependent kinase during cell-cycle progression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    in prostate carcinoma, transitional cell carcinoma of the bladder
    tumoral   LOH    
    in oral squamous cell carcinomas
    tumoral        
    silenced in rapidly metastasizing and metastatic uveal melanomas but not in slowly metastasizing and nonmetastasizing uveal melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS