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FLASH GENE
Symbol LZTR1 contributors: mlc - updated : 07-01-2008
HGNC name leucine-zipper-like transcriptional regulator, 1
HGNC id 6742
Location 22q11.1-q11.2      Physical location : 21.336.557 - 21.353.325
Synonym name leucine-zipper-like regulator-1
Synonym symbol(s) LZTR-1, MGC21205, TCFL2
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388855 22 hypothetical gene supported by BC039313 LOC388856 22 hypothetical gene supported by BC039313 LOC388857 22 similar to KIAA0649 gene product LOC391299 22 similar to Collagen alpha 1(II) chain precursor USP41 22q11.22 ubiquitin specific protease 41 ZNF74 22q11.21 zinc finger protein 74 (Cos52) SCARF2 22q11.21 scavenger receptor class F, member 2 FLJ14360 22q11.21 hypothetical protein FLJ14360 PCQAP 22q11.21 PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein LOC391300 22 similar to hypothetical protein FLJ20297 LOC343839 22q11.21 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC150207 22q11.21 hypothetical gene LOC150207 POM121L4P 22 POM121 membrane glycoprotein-like 4 pseudogene (rat) DKFZp434N035 22q11.21 hypothetical protein DKFZp434N035 PIK4CA 22q11.21 phosphatidylinositol 4-kinase, catalytic, alpha polypeptide SERPIND1 22q11.21 serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 SNAP29 22q11.21 synaptosomal-associated protein, 29kDa CRKL 22q11.21 v-crk sarcoma virus CT10 oncogene homolog (avian)-like FLJ30473 22q11.21-q11.22 hypothetical protein FLJ30473 LZTR1 22q11.1-q11.2 leucine-zipper-like transcriptional regulator, 1 THAP7 22q11.2 THAP domain containing 7 FLJ39582 22q11.2 hypothetical protein FLJ39582 MGC16703 22q11.22 alpha tubulin-like P2RXL1 22q11.21 purinergic receptor P2X-like 1, orphan receptor SLC7A4 22q11.21 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 LOC391301 22 similar to Tubulin alpha-3/alpha-7 chain (Alpha-tubulin 3/7) LOC388858 22 similar to Bcr protein LOC391302 22 hypothetical gene supported by AY358961; NM_014549 LOC376818 22q11.22 E2F transcription factor 6 pseudogene LOC388859 22 similar to Nucleosome binding protein 1 (Nucleosome binding protein 45) (NBP-45) (GARP45 protein) LOC388860 22 similar to Gamma-glutamyltranspeptidase 1 precursor (Gamma-glutamyltransferase 1) (CD224 antigen) LOC388861 22 similar to E2F transcription factor 6 isoform a LOC388862 22 LOC388862 LOC388863 22 similar to dJ831C21.3 (novel protein similar to DKFZP434P211 protein) LOC388864 22 similar to breakpoint cluster region isoform 1 LOC391303 22 similar to Nucleosome binding protein 1 (Nucleosome binding protein 45) (NBP-45) (GARP45 protein) LOC391304 22 similar to KIAA0649 gene product LOC391305 22 similar to Sushi domain (SCR repeat) containing KIAA1666  KIAA1666 protein HIC2 22q11.21 hypermethylated in cancer 2 LOC220686 22q11.22 hypothetical protein LOC220686 LOC150221 22q11.22 similar to hypothetical protein UBE2L3 22q11.22 ubiquitin-conjugating enzyme E2L 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 4332 - 840 - Nacak (2006)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Respiratoryrespiratory tractlarynx  highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain, lung, liver, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six N-terminal kelch motifs
  • basic leucine zipper (bZIP) protein with PEST sequences
  • two BTB/POZ domains at the C terminus (the second mediating the binding to the Golgi complex)
  • HOMOLOGY
    Homologene
    FAMILY BTB-kelch superfamily
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may help stabilize the Gogli complex
  • play important roles during fundamental cellular processes, such as the regulation of cell morphology, migration, and gene expression
  • probable transcriptional regulator that may play a crucial role in embryogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in DiGeorge syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS