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FLASH GENE
Symbol LZIC contributors: - updated : 09-01-2006
HGNC name leucine zipper and CTNNBIP1 domain containing
HGNC id 17497
Location 1p36.22      Physical location : 9.989.777 - 10.002.826
Synonym symbol(s) MGC15436
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     8 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DNB5 1p36.2-p36.1 deleted in neuroblastoma 5 RERE 1p36.1-p36.2 arginine-glutamic acid dipeptide (RE) repeats DKFZp566H0824 1p36.22 hypothetical protein DKFZp566H0824 LOC390994 1 similar to 60S ribosomal protein L23a ENO1 1p36.2 enolase 1, (alpha) LOC148915 1p36.22 hypothetical LOC148915 CA6 1p36.2 carbonic anhydrase VI LOC390995 1 similar to Solute carrier family 2, facilitated glucose transporter, member 5 (Glucose transporter type 5, small intestine) (Fructose transporter) SLC2A5 1p36.2 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 GPR157 1p36.22 G protein-coupled receptor 157 H6PD 1p36.3 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) SSB1 1p36.22 SPRY domain-containing SOCS box protein SSB-1 MGC4399 1p36.22 mitochondrial carrier protein LOC199953 1p36.22 similar to expressed sequence AV028368 PIK3CD 1p36.2 phosphoinositide-3-kinase, catalytic, delta polypeptide CLSTN1 1p36.22 calsyntenin 1 CTNNBIP1 1pter-p36.31 catenin, beta interacting protein 1 LZIC 1p36.22 leucine zipper and CTNNBIP1 domain containing NMNAT1 1p36.2 nicotinamide nucleotide adenylyltransferase 1 CRBPIV 1p36.22 retinoid binding protein 7 UBE4B 1p36.3- ubiquitination factor E4B (UFD2 homolog, yeast) KIF1B 1p36.2 kinesin family member 1B LOC388593 1 LOC388593 PGD 1p36.31 phosphogluconate dehydrogenase CORT 1p36.3-p36.2 cortistatin DFFA 1p36.3-p36.2 DNA fragmentation factor, 45kDa, alpha polypeptide PEX14 1p36.3-p36.2 peroxisomal biogenesis factor 14 LOC163301 1p36.22 similar to BC035954 protein FLJ20321 1p36.22 hypothetical protein FLJ20321 FLJ37118 1p36.22 hypothetical protein FLJ37118 LOC390996 1 similar to Cofilin, non-muscle isoform TARDBP 1p36.22 TAR DNA binding protein AF311304 1p36.22 hypothetical protein AF311304 MASP2 1p36.3-p36.2 mannan-binding lectin serine protease 2 SRM 1p36-p22 spermidine synthase PMSCL2 1p36.22 polymyositis/scleroderma autoantigen 2, 100kDa FRAP1 1p36.3-p36.2 FK506 binding protein 12-rapamycin associated protein 1 CDT6 1p36.3-p36.2 angiopoietin-like factor TERE1 1p36 angiopoietin-like factor KIAA1337 1p36.21 KIAA1337 protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
 thymus   highly
Endocrinepancreas    
 thyroid    
Reproductivefemale systemuteruscervix  
 male systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
leucine zipper domain
HOMOLOGY
interspecies ortholog to murine Lzic
ortholog to chicken lzic
homolog to dog LOC491440
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • inhibiting the interactions between beta-catenin and TCF transcription factors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS