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FLASH GENE
Symbol LYVE1 contributors: mct - updated : 02-04-2008
HGNC name extracellular link domain containing 1
HGNC id 14687
Location 11p15      Physical location : 10.579.412 - 10.590.365
Synonym name
  • hyaluronic acid receptor
  • lymphatic vessel endothelial hyaluronan receptor 1
  • cell surface retention sequence binding protein-1
  • Synonym symbol(s) HAR, LYVE-1, XLKD1, CRSBP-1,
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     6 Exon(s)
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 2310 40 322 - Banerji
    - - - 2600
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselcapillary  highly
    Endocrineneuroendocrinepituitary  highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymphatic vessel    
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectiveadipose  highly
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    physiological period fetal, pregnancy
    Text liver, highly, placenta, lowly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leader peptide,
  • a 212-residues extracellular domain with seven cysteine residues
  • a serine/threonine-rich region and two potential N-linked glycosylation sites
  • a twenty-one amino acid transmembrane domain and a sixty-three-residues cytoplasmic tail
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Xlkd1
    intraspecies homolog to cd44
    Homologene
    FAMILY
    CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • receptor for the glycoaminoglycan hyaluroman
  • playing a role in the regulation of lymphatic vascular function
  • may be playing a role in the autocrine regulation of cell growth of endothelial cells during formation of vessels
  • can function independently of hyaluronan and have implications for the use of LYVE1 as a histological marker for lymphangiogenesis in human pathology
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    text embryonic development
    PATHWAY
    metabolism
    signaling
    a component disulfide-linked homodimer
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hyaluronan
  • binding IGFBP3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    liver cancer, cirrhosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS