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FLASH GENE
Symbol LYPLA2 contributors: mct - updated : 10-07-2013
HGNC name lysophospholipase II
HGNC id 6738
Location 1p36.11      Physical location : 24.117.645 - 24.122.027
Synonym name acyl-protein thioesterase
Synonym symbol(s) APT-2, DJ886K2.4, LPL-I
EC.number 3.1.1.5, 3.1.2.-
DNA
TYPE functioning gene
STRUCTURE 4.38 kb     10 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
C1QA 1p36.3-p34.1 complement component 1, q subcomponent, alpha polypeptide C1QG 1p36.3-p34.1 complement component 1, q subcomponent, gamma polypeptide C1QB 1p36.11 complement component 1, q subcomponent, beta polypeptide EPHB2 1p36.1-p35 EphB2 LOC127309 1p36.11 similar to RIKEN cDNA 4930549C01 KIAA0601 1p36.11 KIAA0601 protein LUZP1 1p36 leucine zipper protein 1 LOC391018 1 similar to RIKEN cDNA 2410002F23 HTR1D 1p35 5-hydroxytryptamine (serotonin) receptor 1D LOC391019 1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) HNRPR 1p36.11 heterogeneous nuclear ribonucleoprotein R ZNF436 1p36 zinc finger protein 436 TCEA3 1p36.11 transcription elongation factor A (SII), 3 UPLC1 1p36.11 up-regulated in liver cancer 1 E2F2 1p36.11 E2F transcription factor 2 ID3 1p36.13-36.12 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein AD7C-NTP 1p36 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein RPL11 1p36.1-p35 ribosomal protein L11 TCEB3 1p36.1 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) HT014 1p36.11 HT014 LYPLA2 1p36.12-p35.1 lysophospholipase II GALE 1p36-p35 galactose-4-epimerase, UDP- HMGCL 1p36.11 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) FUCA1 1p36.1 fucosidase, alpha-L- 1, tissue FLJ35961 1p36.11 hypothetical protein FLJ35961 IL22RA1 1p36.11 interleukin 22 receptor, alpha 1 IL28RA 1p36.11 interleukin 28 receptor, alpha (interferon, lambda receptor) SOM 1p36.11 sister-of-mammalian grainyhead LOC90529 1p36.11 hypothetical protein LOC90529 DJ462O23.2 1p36.12-p35.1 hypothetical protein dJ462O23.2 DSCR1L2 1p35.3-p33 Down syndrome critical region gene 1-like 2 SRRM1 1p36.11 serine/arginine repetitive matrix 1 CLIC4 1p36.11 chloride intracellular channel 4 RUNX3 1p36.11 runt-related transcription factor 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1648 24.61 231 - 2013 23396970
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Lypla2
homolog to rattus Lypla2
homolog to Drosophila CG18815
homolog to Xenopus Xl.8625
homolog to C.elegans K04G2.5
Homologene
FAMILY
  • AB hydrolase 2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalysing the hydrolysis of lysoglycerophospholipids with liberation of a fatty acid
  • is the protein thioesterase involved in the acylation/deacylation cycle operating in GAP43 subcellular distribution
  • LYPLA1, LYPLA2 are cytosolic enzymes that catalyze depalmitoylation of membrane-anchored, palmitoylated HRAS and growth-associated protein-43 (GAP43), respectively
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS