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FLASH GENE
Symbol LYPLA2 contributors: mct - updated : 10-07-2013
HGNC name lysophospholipase II
HGNC id 6738
Location 1p36.11      Physical location : 24.117.645 - 24.122.027
Synonym name acyl-protein thioesterase
Synonym symbol(s) APT-2, DJ886K2.4, LPL-I
EC.number 3.1.1.5, 3.1.2.-
DNA
TYPE functioning gene
STRUCTURE 4.38 kb     10 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1648 24.61 231 - 2013 23396970
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Lypla2
homolog to rattus Lypla2
homolog to Drosophila CG18815
homolog to Xenopus Xl.8625
homolog to C.elegans K04G2.5
Homologene
FAMILY
  • AB hydrolase 2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalysing the hydrolysis of lysoglycerophospholipids with liberation of a fatty acid
  • is the protein thioesterase involved in the acylation/deacylation cycle operating in GAP43 subcellular distribution
  • LYPLA1, LYPLA2 are cytosolic enzymes that catalyze depalmitoylation of membrane-anchored, palmitoylated HRAS and growth-associated protein-43 (GAP43), respectively
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS