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FLASH GENE
Symbol LYPLA1 contributors: mct - updated : 27/10/2008
HGNC name lysophospholipase I
HGNC id 6737
Location 8q11.23      Physical location : 54.958.938 - 55.014.577
Synonym name
  • lysophospholipid-specific lysophospholipase
  • acyl-protein thioesterase-1
  • Synonym symbol(s) LPL1, APT-1, LYSOPLA
    EC.number 3.1.1.5, 3.1.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 55.64 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text
  • using of alternate polyadenylation sites
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2578 24.5 230 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunelymph node   moderately
    Reproductivemale systemtestis  moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Lypla1 (92.2 pc)
    homolog to murine Lypla1 (91.7 pc)
    Homologene
    FAMILY
  • AB hydrolase 2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS
  • acting also as a low lysophospholipase
  • hydrolyzing lysophosphatidylcholine in both monomeric and micellar forms
  • LYPLA1, LYPLA2 are cytosolic enzymes that catalyze depalmitoylation of membrane-anchored, palmitoylated HRAS and growth-associated protein-43 (GAP43), respectively
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS