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FLASH GENE
Symbol LYPD6 contributors: SGE/npt - updated : 07-05-2010
HGNC name LY6/PLAUR domain containing 6
HGNC id 28751
Location 2q23.2      Physical location : 150.187.112 - 150.330.137
Synonym name ly6/PLAUR domain-containing protein 6
Synonym symbol(s) MGC52057
DNA
TYPE functioning gene
STRUCTURE 143.03 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3501 - 171 - Zhang (2010)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   lowly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single LU domain with 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang 2010)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lypd6 (94.7pc)
    homolog to rattus Lypd6 (82.5pc)
    Homologene
    FAMILY
  • Ly-6 superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • down-regulating expression of an AP1 reporter gene in a dose-dependent manner (Zhang 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS