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FLASH GENE
Symbol LYN contributors: mct/npt/pgu - updated : 28-11-2011
HGNC name v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
HGNC id 6735
Location 8q12.1      Physical location : 56.792.385 - 56.923.936
Synonym name tyrosine-protein kinase Lyn
Synonym symbol(s) FLJ26625, JTK8
EC.number 2.7.1.112, 2.7.10.2
DNA
TYPE functioning gene
STRUCTURE 131.55 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MRPL15 8q11.2-q13 mitochondrial ribosomal protein L15 LOC392221 8 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein SOX17 8q11,22 SRY (sex determining region y)-box 17 LOC389659 8 hypothetical gene supported by BC028018 LOC392222 8 similar to RIKEN cDNA 0610038D11 LOC157708 8q11.23 similar to SPC18 protein RP1 8q11.21-q11.23 retinitis pigmentosa 1 (autosomal dominant) LOC392223 8 similar to ribosomal protein L7-like 1 LOC389660 8 similar to polycystin 1-like 3 LOC392224 8 similar to hypothetical protein 4932417K07 KIAA1889 8q11.23 KIAA1889 protein FLJ32370 8q11.23 hypothetical protein FLJ32370 NCOA6IP 8p11 nuclear receptor coactivator 6 interacting protein LYN 8q13 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog PSMC6P 8q11.23 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene RPS20 8 ribosomal protein S20 MOS 8q11 v-mos Moloney murine sarcoma viral oncogene homolog PLAG1 8q12 pleiomorphic adenoma gene 1 MGC2217 RDH-E2 8q12.1 retinal short chain dehydrogenase reductase PENK 8q11.23-q12 proenkephalin LOC389662 8 similar to septin 10 isoform 1 LOC346950 8q11.23 similar to ribosomal protein L37 FLJ20421 8q11.23 hypothetical protein FLJ20421 DKFZP434F122 8q12.1 DKFZP434F122 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3106 58.6 512 expressed in mast cells 2010 20308635
LYN-A
13 - 3043 - 491 expressed in mast cells 2010 20308635
  • LYN-B
  • unlike LYN-A, LYN-B lacks a 21-aa region in the N-terminal unique domain
  • a poor inducer of mast cell degranulation and was less potent in both inositol 1,4,5-triphosphate production and calcium responses
  • differs from LYN-A in its association with INPP5D and in the regulation of calcium responses
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-lobe of the Lyn kinase domain is associated with ACSL3 on the Golgi in a manner that is dependent on LYN conformation but is independent of its kinase activity
  • HOMOLOGY
    interspecies homolog to Yamaguchi sarcoma viral (v-yes-1) oncogene
    Homologene
    FAMILY
  • Src tyrosine kinase family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • exocytosed to the plasma membrane via the Golgi region along the secretory pathway
  • after synthesis in the cytoplasm, accumulates on the Golgi and is subsequently transported to the plasma membrane
  • basic FUNCTION
  • non receptor tyrosine kinase
  • physically linked to AMPA receptor and activated following stimulation of the receptor, then activating the MAP kinase pathway
  • functions as a regulator of imatinib sensitivity in chronic myelogenous leukemia (CML) cells through an unknown mechanism
  • important component of the signal transduction pathway specific to FLT3/ITD
  • playing a role in infectious diseases
  • negative regulator of osteoclastic bone resorption
  • activates protein tyrosine phosphatases in B and mast cells
  • has a role in signal transduction at the cytoplasmic face of the plasma membrane upon extracellular ligand stimulation
  • PECAM1 and the Src family kinase LYN inhibit platelet activation by the glycoprotein VI (GP6) collagen receptor
  • required for PECAM1 tyrosine phosphorylation and subsequent binding of the Src homology 2 domain-containing phosphatase-2, PTPN11
  • contributes to initiation of BCR signaling and is also responsible for feedback inhibition of BCR signaling
  • redox sensor that mediates leukocyte wound attraction
  • with PEAK1 is involved in a basal breast cancer signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    MAP kinase
    a component
  • component of the BCR-ABL signaling complex
  • important component of the signal transduction pathway specific to FLT3/ITD
  • forms a complex with receptor activator of NF-KB (TNFRSF11A), the tyrosine phosphatase, PTPN6, and the adapter protein, Grb2-associated binder 2 (GAB2)
  • forms a multiprotein complex with ANKRD54 and HCLS1 in erythroid cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LYN/PLCB3-mediated regulatory mechanism of PTPN6 and STAT5B activities
  • cell & other
  • membrane associated
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    therapeutic target in the treatment of AML with FLT3/ITD
    immunologyinfectious 
    targets for prevention and treatment of infections
    ANIMAL & CELL MODELS