SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria,interspace
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,nucleus
|
text
| exocytosed to the plasma membrane via the Golgi region along the secretory pathway |
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after synthesis in the cytoplasm, accumulates on the Golgi and is subsequently transported to the plasma membrane |
basic FUNCTION
| non receptor tyrosine kinase |
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physically linked to AMPA receptor and activated following stimulation of the receptor, then activating the MAP kinase pathway |
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functions as a regulator of imatinib sensitivity in chronic myelogenous leukemia (CML) cells through an unknown mechanism |
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important component of the signal transduction pathway specific to FLT3/ITD |
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playing a role in infectious diseases |
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negative regulator of osteoclastic bone resorption |
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activates protein tyrosine phosphatases in B and mast cells |
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has a role in signal transduction at the cytoplasmic face of the plasma membrane upon extracellular ligand stimulation |
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PECAM1 and the Src family kinase LYN inhibit platelet activation by the glycoprotein VI (GP6) collagen receptor |
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required for PECAM1 tyrosine phosphorylation and subsequent binding of the Src homology 2 domain-containing phosphatase-2, PTPN11 |
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contributes to initiation of BCR signaling and is also responsible for feedback inhibition of BCR signaling |
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redox sensor that mediates leukocyte wound attraction |
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with PEAK1 is involved in a basal breast cancer signaling pathway |