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FLASH GENE
Symbol LYN contributors: mct/npt/pgu - updated : 28-11-2015
HGNC name v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
HGNC id 6735
Location 8q12.1      Physical location : 56.792.385 - 56.923.936
Synonym name tyrosine-protein kinase Lyn
Synonym symbol(s) FLJ26625, JTK8
EC.number 2.7.1.112, 2.7.10.2
DNA
TYPE functioning gene
STRUCTURE 131.55 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3106 58.6 512 expressed in mast cells 2010 20308635
LYN-A
13 - 3043 - 491 expressed in mast cells 2010 20308635
  • LYN-B
  • unlike LYN-A, LYN-B lacks a 21-aa region in the N-terminal unique domain
  • a poor inducer of mast cell degranulation and was less potent in both inositol 1,4,5-triphosphate production and calcium responses
  • differs from LYN-A in its association with INPP5D and in the regulation of calcium responses
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-lobe of the Lyn kinase domain is associated with ACSL3 on the Golgi in a manner that is dependent on LYN conformation but is independent of its kinase activity
  • HOMOLOGY
    interspecies homolog to Yamaguchi sarcoma viral (v-yes-1) oncogene
    Homologene
    FAMILY
  • Src tyrosine kinase family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • exocytosed to the plasma membrane via the Golgi region along the secretory pathway
  • after synthesis in the cytoplasm, accumulates on the Golgi and is subsequently transported to the plasma membrane
  • basic FUNCTION
  • non receptor tyrosine kinase
  • physically linked to AMPA receptor and activated following stimulation of the receptor, then activating the MAP kinase pathway
  • functions as a regulator of imatinib sensitivity in chronic myelogenous leukemia (CML) cells through an unknown mechanism
  • important component of the signal transduction pathway specific to FLT3/ITD
  • playing a role in infectious diseases
  • negative regulator of osteoclastic bone resorption
  • activates protein tyrosine phosphatases in B and mast cells
  • has a role in signal transduction at the cytoplasmic face of the plasma membrane upon extracellular ligand stimulation
  • PECAM1 and the Src family kinase LYN inhibit platelet activation by the glycoprotein VI (GP6) collagen receptor
  • required for PECAM1 tyrosine phosphorylation and subsequent binding of the Src homology 2 domain-containing phosphatase-2, PTPN11
  • contributes to initiation of BCR signaling and is also responsible for feedback inhibition of BCR signaling
  • redox sensor that mediates leukocyte wound attraction
  • with PEAK1 is involved in a basal breast cancer signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    MAP kinase
    a component
  • component of the BCR-ABL signaling complex
  • important component of the signal transduction pathway specific to FLT3/ITD
  • forms a complex with receptor activator of NF-KB (TNFRSF11A), the tyrosine phosphatase, PTPN6, and the adapter protein, Grb2-associated binder 2 (GAB2)
  • forms a multiprotein complex with ANKRD54 and HCLS1 in erythroid cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LYN/PLCB3-mediated regulatory mechanism of PTPN6 and STAT5B activities
  • DOK3/GRB2 modulates the balance between activatory and inhibitory LYN functions with the aim to adjust BCR signaling efficiency
  • YES1 and LYN play a role in nuclear translocation of EGFR
  • signaling cascade in which EGFR enhances MCM7 phosphorylation and DNA replication through LYN phosphorylation in human cancer cells
  • cytoplasmic MS4A2, which is not co-localized with FCER1A, may function as a negative regulator, as it can capture important signalling molecules such as LYN
  • PSTPIP2 interacted with LYN and the expression of a dominant negative LYN (LYN DN) overwhelmed the inhibitory effect of PSTPIP2 on differentiation and ERK signaling
  • cell & other
  • membrane associated
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    therapeutic target in the treatment of AML with FLT3/ITD
    immunologyinfectious 
    targets for prevention and treatment of infections
    ANIMAL & CELL MODELS