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FLASH GENE
Symbol LYL1 contributors: mct - updated : 31-08-2010
HGNC name lymphoblastic leukemia derived sequence 1
HGNC id 6734
Location 19p13.2      Physical location : 13.209.843 - 13.213.974
Synonym name
  • class A basic helix-loop-helix protein 18
  • protein lyl-1
    • Synonym symbol(s) bHLHa18
    DNA
    TYPE functioning gene
    STRUCTURE 3.83 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure promoter region revealed potential binding sites for transcription factors HOXA10, LMO2 and NKX2-5 (Nagel 2010)
    MAPPING cloned Y linked   status confirmed
    Map pter - D19S461 /D19S413 - D19S535 - (ICAM1 - LDLR LDLR ) - JUNB - LYL1 /D19S817 - D19S171 - D19S411 - cen
    Authors Collin (96)
    Physical map
    FLJ90396 19p13.2 hypothetical protein FLJ90396 MGC4238 19p13.2 hypothetical protein MGC4238 LOC284393 19p13.2 similar to 60S ribosomal protein L10 (QM protein homolog) MAN2B1 19p13.2-p13.1 mannosidase, alpha, class 2B, member 1 PTD008 19p13.2 PTD008 protein DHPS 19p13.12-p13.11 deoxyhypusine synthase MGC10870 19p13.2 hypothetical protein MGC10870 TNPO2 19p13.2 transportin 2 (importin 3, karyopherin beta 2b) MGC2803 19p13.2 hypothetical protein MGC2803 ASNA1 19q13.3 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) VMD2L1 19p13.2-p13.12 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) HOOK2 19p13.2 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) RNASEH2A 19p13.2 ribonuclease H2, large subunit JUNB 19p13.2 jun B proto-oncogene PRDX2 13q12 peroxiredoxin 2 RTBDN 19p12 retbindin DNASE2 19p13.2 deoxyribonuclease II, lysosomal KLF1 19p13.13-p13.12 Kruppel-like factor 1 (erythroid) GCDH 19p13.2 glutaryl-Coenzyme A dehydrogenase FARSLA 19p13.2 phenylalanine-tRNA synthetase-like, alpha subunit CALR 19p13.3-p13.2 calreticulin RAD23A 19p13.2 RAD23 homolog A (S. cerevisiae) PLINP-1 19p13.2 papillomavirus L2 interacting nuclear protein 1 FLJ38607 19p13.2 hypothetical protein FLJ38607 LOC339375 19p13.13 hypothetical LOC339375 NFIX 19p13.2 nuclear factor I/X (CCAAT-binding transcription factor) LYL1 19p13.2-p13.1 lymphoblastic leukemia derived sequence 1 FLJ20244 19p13.13 hypothetical protein FLJ20244 BTBD14B 19p13.13 BTB (POZ) domain containing 14B STX10 19p13.2 syntaxin 10 ETR101 LOC390891 19 similar to 60S RIBOSOMAL PROTEIN L12 CACNA1A 19p13.2-13.1 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1788 29.81 280 - San-Marina (2008)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic helix-loop-helix (HLH) protein
    • HOMOLOGY
    Homologene
    FAMILY
  • BHLH family
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in DNA binding throught dimerization with another BHLH protein
  • required for fetal and adult hematopoietic stem cell function and B-cell differentiation (Capron 2006)
  • controls the expression of molecules involved in the stabilization of vascular structuresand plays a role for in the postnatal maturation of newly formed blood vessels (Pirot 2010)
  • important for B cell development (Souroullas 2009)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with BHLH proteins
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • CREB1 binding partner for LYL1 but not for TAL1 (interaction between LYL1 and CREB1 involves the N terminal domain of LYL1 and the Q2 and KID domains of CREB1) (San Marina 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation --low  
    t(7;19)(q35;p13) in T cell leukemia with worse response to treatment
    tumoral     --other  
    with TAL1, aberrantly over-expressed in leukemia as a result of chromosomal translocations (San-Marina 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lyl-1 null mice are viable and display normal blood cell counts, except for a reduced number of B cells resulting from a partial block after the pro-B stage (Capron 2006)