Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | LY96 | contributors: mct - updated : 18-02-2016 |
HGNC name | lymphocyte antigen 96 |
HGNC id | 17156 |
|
Location | 8q21.11 Physical location : 74.903.586 - 74.941.305 |
Synonym name | |
| |
Synonym symbol(s) | MD-2, ESOP-1, MD2, ly-96 |
DNA |
TYPE | functioning gene |
STRUCTURE | 41.23 kb 5 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
---|
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
---|
EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
|
tissue |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
|
conjugated | GlycoP |
HOMOLOGY |
interspecies | ortholog to murine Ly96 |
Homologene |
FAMILY |
CATEGORY | adaptor , antigen |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,organelle,endosome | |
text | trafficking to and from the cell surface and the Golgi apparatus |
basic FUNCTION | |
| |
| |
|
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | immunity/defense , inflammation |
PATHWAY |
metabolism |
signaling | signal transduction |
required for LPS signaling of TLR4 |
a component | |
|
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
| |
| |
| |
|
cell & other | lipopolysaccharides |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |
mice MD-2(-/-) do not response to LPS,but survive to endotoxin shock |