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FLASH GENE

Symbol

LY9

contributors: mct - updated : 16-02-2016

HGNC name	lymphocyte antigen 9
HGNC id	6730

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q23.3      Physical location : 160.765.927 - 160.798.043
Synonym name	T-lymphocyte surface antigen Ly-9
	cell surface molecule Ly-9
	signaling lymphocytic activation molecule 3
Synonym symbol(s)	CD229, RP11-312J18.1, SLAMF3, hly9, mLY9

DNA

TYPE	functioning gene
STRUCTURE	32.18 kb     10 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002348 10 - 2550 NP_002339 - 655 - 2001 11369645 Ia NM_001033667 3 - 1525 NP_001028839 - 193 - 2001 11369645 Ib NM_001261456 10 - 2508 NP_001248385 - 641 - 2001 11369645 NM_001261457 9 - 2280 NP_001248386 - 565 - 2001 11369645

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma       Homo sapiens Connective bone       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Blood/Hematopoietic thymocyte Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four immunoglobulin like domains

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Ly-9

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

adhesion , antigen

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	putatively involved in adhesion reaction between T lymphocyte and accessory cells
	SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
	plays a unique role as an inhibitory cell surface receptor regulating the size of the thymic innate CD8(+) T cell pool and the development of invariant NKT cells.
	LY9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses
	is a specific marker of normal hepatocytes and plays a potential role in the control of proliferation of HCC cells
	plays a role during Hepatitis C virus (HCV) entry, likely by enhancing entry of viral particle within hepatocytes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

LY9/SLAMF6 signaling mediates increased nuclear abundance and recruitment of RORC to the proximal IL17A promoter, resulting in increased trans-activation and gene expression

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   LY9 and SLAMF6 expression is increased on the surface of SLE T cells compared with normal cells tumoral     --low   in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   could serve as a novel target for the treatment of B cell-related diseases

ANIMAL & CELL MODELS

Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies