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FLASH GENE
Symbol LY75 contributors: mct - updated : 14-11-2017
HGNC name lymphocyte antigen 75
HGNC id 6729
Location 2q24.2      Physical location : 160.659.868 - 160.761.262
Synonym name
  • C-type lectin domain family 13 member B
  • Synonym symbol(s) DEC-205, CD205, CLEC13B, GP200-MR6, DEC205, LY-75
    DNA
    TYPE functioning gene
    STRUCTURE 101.40 kb     35 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    GALNT5 2q24.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) KIAA1189 2q24.2 KIAA1189 protein PSCDBP 2q11.2 pleckstrin homology, Sec7 and coiled-coil domains, binding protein ACVR1C 2q24-q31 activin A receptor, type IC ACVR1 2q23-q24 activin A receptor, type I UPP2 2q24.2 uridine phosphorylase 2 LOC130940 2q24.2 hypothetical protein BC015395 PKP4 2q23-q31 Plakophilin 4 LOC391456 2 similar to KIAA0181 LOC92196 2q24.2 similar to death-associated protein OR7E89P 2q31.3 olfactory receptor, family 7, subfamily E, member 89 pseudogene LOC391457 2 similar to putative taste receptor HTR2 OR7E90P 2q31.3 olfactory receptor, family 7, subfamily E, member 90 pseudogene MGC23908 2 similar to RNA polymerase B transcription factor 3 KIAA1728 2q24.2 KIAA1728 protein FLJ36175 2q24.2 hypothetical protein FLJ36175 BAZ2B 2q23-q24 bromodomain adjacent to zinc finger domain, 2B AXOT 2q24.2 axotrophin DCL-1 2q24.2 type I transmembrane C-type lectin receptor DCL-1 LY75 2p24 lymphocyte antigen 75 PLA2R1 2q23-q24.1 phospholipase A2 receptor 1, 180kDa ITGB6 2q24-q31 integrin, beta 6 RBMS1 2q24.2 RNA binding motif, single stranded interacting protein 1 TANK 2q24-q31 TRAF family member-associated NFKB activator PSMD14 2q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 TBR1 2q24 T-box, brain, 1 LOC285116 2q24.3 ELYS transcription factor-like protein TMBS62 pseudogene LOC391458 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SLC4A10 2q23-q24 solute carrier family 4, sodium bicarbonate transporter-like, member 10 DPP4 2q24.3 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) GCG 2q36-q37 glucagon FAP 2q23 fibroblast activation protein, alpha
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 8919 - 1873 - 1998 10233701
    35 - 6936 205 1722 - 1998 9553150
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Respiratoryrespiratory tracttrachea  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NH(2) terminal cysteine-rich and fibronectin type II domains
  • a signal peptide
  • 10 C-type lectin domains
  • ricin b-type lectin domain
  • a transmembrane domain and a cytoplasmic tail
  • an internalization sequence in its cytoplasmic tail
  • HOMOLOGY
    intraspecies homolog to macrophage mannose receptor (MMR)
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • putative antigen-uptake receptor on dendritic cells
  • acting as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment
  • plays an important role in thymocyte development
  • acts as a recognition receptor for dying cells, potentially providing an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance
  • endocytic receptor that is expressed at high levels by cortical thymic epithelial cells and by dendritic cell (DC) subsets, including the splenic CD8+ DC population that is responsible for cross-presentation of apoptotic cell-derived antigens
  • mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells
  • has endocytic capacity, recycles through late endosomal/lysosomal compartments, and facilitates antigen presentation when targeted with antigen-bearing monoclonal antibodies
  • critical role for CD205(+) cDCs in the regulation of T-cell immunity and homeostasis
  • facilitates dendritic cells (DC) maturation induced by CpG oligonucleotides (ODN)
  • does not play an overt role in T cell development or selection
  • is one of the major endocytotic receptors on dendritic cells and has been widely used for vaccine generation against viruses and tumors
  • is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism
  • modulates cellular phenotype and metastatic potential of ovarian cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly bound CpG ODN and facilitated uptake by CD8+ DC, the key producers of IL12
  • cell & other
  • LY75 only binds to apoptotic and necrotic cells at acidic pH, whereas live cells cannot be recognized by LY75 at either acidic or basic conditions
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion protein between LY75 and a novel C-type lectin CD302 in Hodgkin's lymphoma
    tumoral     --over  
    in advanced epithelial ovarian cancer (EOC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • sensitive and specific marker for thymoma but not thymic carcinoma
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    LY75 targeting should be explored as a vaccination approach against EBV-associated malignancies
    immunologyinfectious 
    LY75 targeting should be explored as a vaccination approach against symptomatic primary EBV infection
    ANIMAL & CELL MODELS