Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LY6K contributors: mct - updated : 27-03-2019
HGNC name lymphocyte antigen 6 family member K
HGNC id 24225
Location 8q24.3      Physical location : 143.781.528 - 143.785.582
Synonym name
  • up-regulated in lung cancer 10
  • cancer/testis antigen 97
    • Synonym symbol(s) FLJ35226, CT97, ly-6K, URLC10, HSJ001348
    DNA
    TYPE functioning gene
    STRUCTURE 4.09 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1994 - 120 - 2012 22988241
    3 - 1747 17 165 . GPI-anchored form 2012 22988241
    3 - 1715 12 105 - 2012 22988241
  • water-soluble (non-membrane) form
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • LY6K is a newly identified factor involved in sperm fertilizing ability
  • overexpression of LY6K suppresses T cell development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TEX101 is physically associated with LY6K within the testis, and TEX101 collaborates likely with LY6K on the cell membrane and may play a role in spermatogenesis
  • TEX101 is associated with LY6K during spermatogenesis in testis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer patients with distant metastases than those without distant metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • a cancer-testis antigen, LY6K, should be useful as a new type of tumor biomarker
    • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    LY6K is a potential therapeutic target for cancer
    ANIMAL & CELL MODELS