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FLASH GENE
Symbol LY6G6F contributors: mct - updated : 19-01-2011
HGNC name lymphocyte antigen 6 complex, locus G6F
HGNC id 13933
Location 6p21.33      Physical location : 2.960.255 - 31.678.372
Synonym name
  • chromosome 6 open reading frame 21
  • GF protein
  • Synonym symbol(s) G6f, NG32, C6orf21, LY6G6D
    DNA
    TYPE functioning gene
    STRUCTURE 3.69 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 898 - 297 - 2003 12852788
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative leader peptide
  • a transmembrane segment
  • four extracellular Ig-like domains
  • an immunoreceptor tyrosine-based activation motif (ITAM)
  • a cytoplasmic tail 40 AAs in length with a tyrosine phosphorylation site, found in a consensus-binding motif (YXN) for the Src homology 2 domains of GRB2 and GRB7
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobin (Ig) superfamily
  • CATEGORY adaptor , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • putative cell-surface receptor coupling with downstream signal transduction pathways involving GRB2 and GRB7, including the Ras-MAP kinase pathway
  • platelet GRB2-binding membrane adapter
  • ITAM-bearing of Ly6G6F suggests that the molecule plays an important role in cell activation, and LY6G6F expression by erythrocytes potentially have functional overlap potential with thrombocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with both GRB2 and GRB7 is mediated through the Src homology 2 domains of these two proteins and is dependent on the phosphorylation of LY6G6F
  • cell & other
    REGULATION
    Other specifically phosphorylated on Tyr-281 in response to platelet activation by GP6, providing a docking site for the adapter GRB2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS