Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LXN contributors: mct - updated : 28-03-2009
HGNC name latexin
HGNC id 13347
Location 3q25.32      Physical location : 158.384.203 - 158.390.482
Synonym name
  • tissue carboxypeptidase inhibitor
  • endogenous carboxypeptidase inhibitor
  • Synonym symbol(s) ECI, TCI
    DNA
    TYPE functioning gene
    STRUCTURE 6.27 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • lacks typical TATA or CAAT boxes but has several GC-rich sites
  • up and downstream regulatory elements involved in the control of cell type-specific expression
  • MAPPING cloned Y linked N status provisional
    Physical map
    MME 3q25.1-q25.2 membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) LOC256283 3q25.2 hypothetical LOC256283 KIAA1069 3q26.1 hypothetical LOC256283 FLJ31139 3q25.31 hypothetical protein FLJ31139 SLC33A1 3q25.31 solute carrier family 33 (acetyl-CoA transporter), member 1 GMPS 3q24 guanine monphosphate synthetase LOC389168 3 similar to template acyivating factor-I alpha LOC344760 3q25.31 similar to seven transmembrane helix receptor MRE11B 3q25 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) KCNAB1 3q26.1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 SSR3 3q25.31 signal sequence receptor, gamma (translocon-associated protein gamma) TIPARP 3q25.31 TCDD-inducible poly(ADP-ribose) polymerase LOC389169 3 hypothetical gene supported by BC001951; NM_006191 LOC389170 3 similar to hypothetical protein FLJ14957 LOC339892 3q25.31 similar to Death domain containing protein CRADD (Caspase and RIP adaptator with death domain) (RIP associated protein with a death domain) CCNL1 3q26.1 cyclin L1 LOC391589 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FLJ12604 3q24-q25 hypothetical protein FLJ12604 PTX3 3q21-q25 pentaxin-related gene, rapidly induced by IL-1 beta LOC152078 3q25.32 hypothetical protein BC010062 SHOX2 3q25-q26.1 short stature homeobox 2 MGC12197 3q25.32 BM-011 protein MLF1 3q25.1 myeloid leukemia factor 1 EFG1 3q25.1-q26.2 myeloid leukemia factor 1 LXN 3q25-q31 myeloid leukemia factor 1 RARRES1 3q25.31 retinoic acid receptor responder (tazarotene induced) 1 FLJ14153 3q25.32 hypothetical protein FLJ14153 GPR79 3q26 G protein-coupled receptor 79 pseudogene SCHIP1 3q25.3-q27 schwannomin interacting protein 1 IL12A 3q25.1-q25.3 interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) LOC389171 3 similar to bromodomain containing 7; bromodomain protein; bromodomain-containing 7 LOC391590 3 similar to hypothetical protein KIAA1374 3q25.33-q26.1 KIAA1374 protein SMC4L1 3q26.1 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) TSBF1 3q26.1 tumor suppressor TSBF1 KPNA4 3q25.33 karyopherin alpha 4 (importin alpha 3) LOC90133 3q26.1 hypothetical protein LOC90133 FLJ22595 3q26.1 hypothetical protein FLJ22595 LOC389172 3 LOC389172 PPM1L 3q26.1 protein phosphatase 1 (formerly 2C)-like B3GALT3 3q25 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 CGI-07 3q26.1 CGI-07 protein ADMP 3q26.1 ADMP LOC285214 3q26.1 similar to 60S ribosomal protein L23a LOC131149 3q26.1 similar to otolin-1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1132 29 222 - Kadouchi (2009)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouthtongue   
    Endocrineparathyroid   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N- and C-terminal domains
  • an alpha helix enveloped by a curved beta sheet, separated by a connecting segment
  • potential heparin/heparan sulfate-binding sites
  • two nearly identical domains that have a high conformational homology with the cystatins (Kadouchi 2009)
  • HOMOLOGY
    interspecies homolog to rattus carboxypeptidase A inhibitor
    intraspecies homolog to cystatins
    Homologene
    FAMILY protease inhibitor I47 (latexin) family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear localization of latexin in chondrocytes appearing during fracture repair (Kadouchi 2009)
    basic FUNCTION
  • specific inhibitor of carboxypeptidase A
  • metallocarboxypeptidases containing a characteristic alpha/beta hydrolase fold
  • plays an important role in regulating the activity of hematopoietic stem cells (Kadouchi 2009)
  • regulator of hematopoietic stem cells
  • involved in BMP2-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration (Kadouchi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CPA4/LXN complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction between latexin and heparan sulfate during extracellular matrix synthesis in cartilage (Kadouchi 2009)
    cell & other
    REGULATION
    induced by BMP2 in RUNX2-deficient mesenchymal cells during chondrocyte and osteoblast differentiation (Kadouchi 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the early phase of bone fracture (Kadouchi 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS