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FLASH GENE
Symbol LXN contributors: mct - updated : 28-03-2009
HGNC name latexin
HGNC id 13347
Location 3q25.32      Physical location : 158.384.203 - 158.390.482
Synonym name
  • tissue carboxypeptidase inhibitor
  • endogenous carboxypeptidase inhibitor
  • Synonym symbol(s) ECI, TCI
    DNA
    TYPE functioning gene
    STRUCTURE 6.27 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • lacks typical TATA or CAAT boxes but has several GC-rich sites
  • up and downstream regulatory elements involved in the control of cell type-specific expression
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1132 29 222 - Kadouchi (2009)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouthtongue   
    Endocrineparathyroid   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N- and C-terminal domains
  • an alpha helix enveloped by a curved beta sheet, separated by a connecting segment
  • potential heparin/heparan sulfate-binding sites
  • two nearly identical domains that have a high conformational homology with the cystatins (Kadouchi 2009)
  • HOMOLOGY
    interspecies homolog to rattus carboxypeptidase A inhibitor
    intraspecies homolog to cystatins
    Homologene
    FAMILY protease inhibitor I47 (latexin) family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear localization of latexin in chondrocytes appearing during fracture repair (Kadouchi 2009)
    basic FUNCTION
  • specific inhibitor of carboxypeptidase A
  • metallocarboxypeptidases containing a characteristic alpha/beta hydrolase fold
  • plays an important role in regulating the activity of hematopoietic stem cells (Kadouchi 2009)
  • regulator of hematopoietic stem cells
  • involved in BMP2-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration (Kadouchi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CPA4/LXN complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction between latexin and heparan sulfate during extracellular matrix synthesis in cartilage (Kadouchi 2009)
    cell & other
    REGULATION
    induced by BMP2 in RUNX2-deficient mesenchymal cells during chondrocyte and osteoblast differentiation (Kadouchi 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the early phase of bone fracture (Kadouchi 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS