basic FUNCTION
| specific inhibitor of carboxypeptidase A |
|
metallocarboxypeptidases containing a characteristic alpha/beta hydrolase fold |
|
plays an important role in regulating the activity of hematopoietic stem cells (Kadouchi 2009) |
|
regulator of hematopoietic stem cells |
|
involved in BMP2-induced chondrocyte differentiation and plays an important role in skeletogenesis and skeletal regeneration (Kadouchi 2009) |
|
inhibits the self-renewal of hematopoietic stem cells (HSCs) by facilitating the lodgment of HSCs within a bone marrow niche to maintain HSC homeostasis |
|
plays an important role in the maintenance of homeostatic hematopoiesis, and it may lead to development of safe and effective approaches to manipulate HSCs for clinical benefit |
|
potential role for LXN in retinoid signaling and inflammatory pathways |
|
LXN is a novel regulator for morphological maintenance of endothelial cells (ECs), and LXN deficiency has a protective effect on vascular homeostasis |
|
carboxypeptidase inhibitor, playing important role in the proliferation and differentiation of stem cells |
|
LXN is a key positive regulator of adipocyte differentiation |