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FLASH GENE
Symbol LVRN contributors: mct - updated : 09-09-2005
Location 5q23.1      Physical location : -
Genatlas name laeverin
Synonym symbol(s) FLJ90650, APQ, LAEV, MGC125378, MGC125379
DNA
TYPE functioning gene
STRUCTURE 65.00 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 4502 - 990 - Maruyama (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnerve    
Reproductivefemale systemovary   
 female systemplacenta   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text in embryo-derived extravillous trophoblasts that invades the uterus during placentation, placenta, extravillous trophoblast
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transmembrane domain near the N-terminus
  • a HEXXHX(18)E gluzincin motif with a zinc-binding active site,
  • characteristic of the M1 family of aminopeptidases, although the exopeptidase motif of the family, GAMEN, is uniquely substituted for the HAMEN sequence
    HOMOLOGY
    Homologene
    FAMILY
  • membrane-bound gluzincin metallopeptidases family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION bestatin-sensitive leucine aminopeptidase that may play important roles in placentation by regulating biological activity of key peptides at theembryo-maternal interface
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein able to cleave the N-terminal amino acid of several peptides such as angiotensin III, kisspeptin-10, and endokinin C, which are abundantly expressed in the placenta
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS