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FLASH GENE
Symbol LUZP1 contributors: KTN/npt - updated : 15-01-2009
HGNC name leucine zipper protein 1
HGNC id 14985
Location 1p36.12      Physical location : 23.410.515 - 23.495.351
Synonym name zona pellucida glycoprotein 1 (sperm receptor)
Synonym symbol(s) LUZP, KIAA0601, FLJ35697
DNA
TYPE functioning gene
STRUCTURE 83.89 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map D1S2698 - LUZP1 - D1S458 - LUZP1 - D1S2734 - D1S482
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 8487 120.1 1076 - -
  • encode the same protein than variant 2
  • - - 8421 120.1 1076 - -
  • differing in the 5' UTR compared to variant 1
  • encode the same protein than variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three leucine zipper motifs at the NH2 terminus
  • three nuclear localization signals
  • a large number of putative Ser/Thr phosphorylation sites
  • conjugated PhosphoP
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to chimpanzee LUZP1 (98.8 pc)
    homolog to cow LUZP1 (85 pc)
    homolog to murine Luzp1 (81.1 pc)
    homolog to rattus Luzp1 (82.8 pc)
    homolog to chicken LUZP1 (57.8 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • implicated as negative transcription regulator by forming a nonfunctional heterodimeric complex with those transcriptional factors containing the basic domains
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • establishment of a knockout mouse strain with a lacZ knock-in (Luzp-KO/lacZ-KI) to explore the role in brain development (Hsu, 2008)