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FLASH GENE
Symbol LTBR contributors: SGE/npt - updated : 31-05-2010
HGNC name lymphotoxin beta receptor (TNFR superfamily, member 3)
HGNC id 6718
Location 12p13.31      Physical location : 6.493.356 - 6.500.732
Synonym name
  • TNFR superfamily, member 3
  • tumor necrosis factor C receptor
  • tumor necrosis factor receptor 2-related protein
  • Synonym symbol(s) TNFRRP, TNFRSF3, CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR2-RP
    DNA
    TYPE functioning gene
    STRUCTURE 7.38 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    CD9 12p13.31 CD9 antigen (p24) FLJ10665 12p13.32 hypothetical protein FLJ10665 TNFRSF1A 12p13.2 tumor necrosis factor receptor superfamily, member 1A SCNN1A 12p13.3 sodium channel, nonvoltage-gated 1 alpha LTBR 12p13.31 lymphotoxin beta receptor (TNFR superfamily, member 3) LOC390283 12 hypothetical gene supported by X15940; NM_000993 LOC390284 12 similar to signal recognition particle 14kDa (homologous Alu RNA binding protein); signal recognition particle 14kD (homologous Alu RNA-binding protein); signal recognition particle 14kD (homologous Alu RNA binding protein) TNFRSF7 12p13 tumor necrosis factor receptor superfamily, member 7 TAPBP-R 12p13.31 TAP binding protein related VAMP1 12p13.31-p13.2 vesicle-associated membrane protein 1 (synaptobrevin 1) PKP2P1 12p13 vesicle-associated membrane protein 1 (synaptobrevin 1) MRPL51 12p13.3-p13.1 mitochondrial ribosomal protein L51 CNAP1 12p13.3 chromosome condensation-related SMC-associated protein 1 GAPD 12p13.31 glyceraldehyde-3-phosphate dehydrogenase HOM-TES-103 12p13.3 HOM-TES-103 tumor antigen-like NOL1 12p13.31 nucleolar protein 1, 120kDa CHD4 12p13 chromodomain helicase DNA binding protein 4 GPR92 12p13.32 G protein-coupled receptor 92 ACRBP 12p13.32 acrosin binding protein ING4 12p13.32 inhibitor of growth family, member 4 ZNF384 12p12 zinc finger protein 384
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2136 - 435 - Crowe (1994)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     stomach   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Urinarybladder   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    Blood/Hematopoieticleukocyte
    Respiratoryalveolar macrophage
    cell lineage myeloid lineages but not on T and B cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracytoplasmic cysteine-rich pseudorepeats
  • a small cytoplasmic domain with the serine/threonine kinase but lacking the DEATH domain
  • four TNFR-CYS repeats
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor TNFR superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 transmembrane protein
    basic FUNCTION
  • specifically binding to the lymphotoxin membrane form and thus playing a role in the development and organization of lymphoid tissues and transformed cells
  • promoting apoptosis via TRAF3 and TRAF5
  • is required for liver regeneration, hepatitis and hepatic lipid metabolism (Tumanov 2007)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • self-associating
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAF2 and TNFSF14 (TRAF2, an important effector molecule of TNF signaling, plays a critical, nonredundant role in TNFSF14-LTBR signaling)
  • interacts with HCV core protein
  • receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFSF14
  • interacting with TRAF3, TRAF4, TRAF5
  • ZMYND11 abrogates LTBR function through a protein-protein interaction
  • cell & other
    REGULATION
    Other negatively regulated by TRAF3 (Bista 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • constitutively inducing NF-KappaB activation and it may be associated with autonomous growth of melanoma cells (Dhawan 2008)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • engagment of Ltbr by Tnfsf14 is essential for both intestinal inflammation and hyperserum IgA syndrome in a murine model that spontaneously develops T cell-mediated intestinal inflammation (Wang 2004)