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FLASH GENE
Symbol LTB4R2 contributors: mct - updated : 26-08-2013
HGNC name leukotriene B4 receptor 2
HGNC id 19260
Location 14q12      Physical location : 24.779.356 - 24.781.259
Synonym name
  • seven transmembrane receptor leukotriene B4
  • LTB4 receptor JULF2
  • leukotriene B4 receptor BLT2
  • seven transmembrane receptor BLTR2
  • Synonym symbol(s) BLT2, JULF2, BLTR2, LTB4-R2, NOP9
    DNA
    TYPE functioning gene
    STRUCTURE 1.90 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • intronless
  • embedded in the promoter region of LTB4R
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC90668 14q11.2 hypothetical protein BC008134 CPNE6 14q11.2 copine VI (neuronal) NRL 14q11.1-q11.2 neural retina leucine zipper PCK2 14q11.2-q12 phosphoenolpyruvate carboxykinase 2 (mitochondrial) WDR23 14q11.2 WD repeat domain 23 LOC161247 14q11.2 similar to 1110028A07Rik protein PSME1 14q11.2 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) C14orf122 14q11.2 chromosome 14 open reading frame 122 PSME2 14q11.2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) RNF31 14q11.2 ring finger protein 31 ISGF3G 14q11.2 interferon-stimulated transcription factor 3, gamma 48kDa REC8L1 14q11.2-q12 REC8-like 1 (yeast) IPO4 14q11.2 importin 4 TM9SF1 14q11.2 transmembrane 9 superfamily member 1 C14orf20 14q11.2 chromosome 14 open reading frame 20 C14orf123 14q11.2 chromosome 14 open reading frame 123 MGC5987 14q11.2 hypothetical protein MGC5987 NEDD8 14q11.2 neural precursor cell expressed, developmentally down-regulated 8 GMPR2 14q11.2 guanosine monophosphate reductase 2 TINF2 14q11.2 TERF1 (TRF1)-interacting nuclear factor 2 TGM1 14q11.2 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) RABGGTA 14q11.2 Rab geranylgeranyltransferase, alpha subunit DHRS1 14q11.2 dehydrogenase/reductase (SDR family) member 1 C14orf21 14q11.2 chromosome 14 open reading frame 21 CIDEB 14q11.2 cell death-inducing DFFA-like effector b LTB4R2 14q11.2-q12 leukotriene B4 receptor 2 LTB4R 14q11.2-q12 leukotriene B4 receptor ADCY4 14q11.2 adenylate cyclase 4 RIPK3 14q11.2 receptor-interacting serine-threonine kinase 3 NFATC4 14q11.2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 KIAA1305 14q11.2 KIAA1305 HCDI
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2252 - 219 - -
    2 - 1560 - 358 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularvessel     Homo sapiens
    Digestiveintestinesmall intestine   
    Endocrineneuroendocrinepituitary   
     pancreas    
    Lymphoid/Immunethymus    
    Reproductivefemale systemovary   
     male systemtestis   
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Cardiovascularendothelial cell Homo sapiens
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven membrane spanning domain (7TM)
    HOMOLOGY
    intraspecies homolog to BLT
    Homologene
    FAMILY rhodopsin family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • chemotactic mediator for inflammation
  • potent activator and chemoattractant for leukocytes and is implicated in several inflammatory diseases
  • plays an essential role in mediating VEGF-induced angiogenesis
  • unique receptor for 5-lipoxygenase- and cyclooxygenase-1-derived lipid mediators, and is a novel target for therapies directed at treating inflammation associated with arthritis
  • involved in multiple cellular responses, including chemotaxis
  • key regulator of AR expression and will contribute to the development of novel therapies for AR-positive prostate cancers, including androgen-responsive and castration-resistant prostate cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • LTB(4)-BLT signaling pathway may negatively regulate preadipocyte differentiation via induction of TGFBI expression as a rate-limiting system to control adipocyte differentiation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LTB4
  • RANBP9 acts as a negative regulator of LTB4R2
  • cell & other
    REGULATION
    Phosphorylated by AKT1 (AKT1 phosphorylates LTB4R2 at its C-terminal Thr(355) residue and this event is critical for LTB4R2-mediated chemotactic responses)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the highly aggressive human breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    potential target for anti-bladder cancer therapy
    ANIMAL & CELL MODELS