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FLASH GENE
Symbol LTB4R contributors: mct/npt - updated : 19-03-2010
HGNC name leukotriene B4 receptor
HGNC id 6713
Location 14q12      Physical location : 24.780.704 - 24.787.241
Synonym name
  • purinoceptor P2Y type 7, group 1
  • chemokine receptor-like 1
  • G protein-coupled receptor 16
  • chemoattractant receptor-like 1
  • Synonym symbol(s) CMKRL1, P2RY7, BLT1, BLTR, GPR16, LTB4R1, LTBR1, P2Y7
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    STRUCTURE 6.35 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • promoter region embedding BLTR2
  • MAPPING cloned Y linked   status confirmed
    Physical map
    LOC90668 14q11.2 hypothetical protein BC008134 CPNE6 14q11.2 copine VI (neuronal) NRL 14q11.1-q11.2 neural retina leucine zipper PCK2 14q11.2-q12 phosphoenolpyruvate carboxykinase 2 (mitochondrial) WDR23 14q11.2 WD repeat domain 23 LOC161247 14q11.2 similar to 1110028A07Rik protein PSME1 14q11.2 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) C14orf122 14q11.2 chromosome 14 open reading frame 122 PSME2 14q11.2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) RNF31 14q11.2 ring finger protein 31 ISGF3G 14q11.2 interferon-stimulated transcription factor 3, gamma 48kDa REC8L1 14q11.2-q12 REC8-like 1 (yeast) IPO4 14q11.2 importin 4 TM9SF1 14q11.2 transmembrane 9 superfamily member 1 C14orf20 14q11.2 chromosome 14 open reading frame 20 C14orf123 14q11.2 chromosome 14 open reading frame 123 MGC5987 14q11.2 hypothetical protein MGC5987 NEDD8 14q11.2 neural precursor cell expressed, developmentally down-regulated 8 GMPR2 14q11.2 guanosine monophosphate reductase 2 TINF2 14q11.2 TERF1 (TRF1)-interacting nuclear factor 2 TGM1 14q11.2 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) RABGGTA 14q11.2 Rab geranylgeranyltransferase, alpha subunit DHRS1 14q11.2 dehydrogenase/reductase (SDR family) member 1 C14orf21 14q11.2 chromosome 14 open reading frame 21 CIDEB 14q11.2 cell death-inducing DFFA-like effector b LTB4R2 14q11.2-q12 leukotriene B4 receptor 2 LTB4R 14q11.2-q12 leukotriene B4 receptor ADCY4 14q11.2 adenylate cyclase 4 RIPK3 14q11.2 receptor-interacting serine-threonine kinase 3 NFATC4 14q11.2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 KIAA1305 14q11.2 KIAA1305 HCDI
    RNA
    TRANSCRIPTS type messenger
    text with two alternatively spliced isoforms, 7.5 and 5kb (Owman)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2723 - 352 - Maier (1997)
    2 - 4331 - 352 - Maier (1997)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines osteoblastic and brain cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the regulation of the inflammatory system
  • predominantly responding to ATP, involved in the regulation of cardiac muscle contraction
  • major neutrophil chemotactic factor released from the intraluminal thrombus of abdominal aortic aneurysms (Houard 2009)
  • G-protein-coupled receptors for leukotriene B4 functioning in host defense, inflammation, and immunity (Kuniyeda 2007)
  • in granulocytes transducing intracellular signals through the Gi- and G16-classes of G proteins, which inhibit cAMP production and raise the intracellular calcium concentration (Hikiji 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand LTB4 (LTB4 is produced in osteoclasts and activates LTB4R in an autocrine/paracrine manner) (Hikiji 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • inhibition of LTB4R functions may represent a strategy for preventing bone resorption diseases (potential therapeutic target for bone resorption diseases) (Hikiji 2009)
  • ANIMAL & CELL MODELS
  • osteoclasts from Blt1-deficient mice showed reduced calcium resorption activities compared with wild-type osteoclasts (Hikiji 2009)