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FLASH GENE

Symbol

LST1

contributors: - updated : 18-05-2004

HGNC name	leukocyte specific transcript 1
HGNC id	14189

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.3      Physical location : 2.839.498 - 31.556.685
Synonym name	leukocyte specific transcript 1
	B144 protein
	activating natural killer receptor p30
	lymphocyte antigen 117
Synonym symbol(s)	D6S49E,B144

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site   HRE
text structure	DNA binding site

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	several alternatively spliced isoforms (I,S) (de Baey,Rollinger-Holzinjer)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CLST1 - - 1000 30 190 - - 14 - - - 640 - 97 - de Baey - - - 630 - 91 - de Baey CLST1-E - - 500 - 53 - de Baey CLST1-J - - 310 - 43 - Rollinger-Holzinjer LST1-K - - 360 - 59 - Rollinger-Holzinjer LST1-L - - 240 - 47 - Rollinger-Holzinjer LST1-M - - 290 - 35 - Rollinger-Holzinjer LST1-N - - 220 - 13 - Rollinger-Holzinjer B144 - - 800 - - - Abraham 1C7 - - 1200 - 117 - Nalabolu LST1/E - splicing 500 - 53 - de Baey LST1/A - splicing 640 - 97 - de Baey LST1/C - splicing 630 - 91 - de Baey

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	a 120AA extracellular region forming a V-type Ig-like domain with two potential N glycosylation sites
	a 33aa cytoplasmic tail lacking an immunoreceptor tyrosine-based active motif (ITAM)

HOMOLOGY

interspecies	homolog to murine B144 transcript
	homolog to murine B144

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

interferon gamma inducible protein

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS