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FLASH GENE
Symbol LST1 contributors: - updated : 18-05-2004
HGNC name leukocyte specific transcript 1
HGNC id 14189
Location 6p21.3      Physical location : 2.839.498 - 31.556.685
Synonym name
  • leukocyte specific transcript 1
  • B144 protein
  • activating natural killer receptor p30
  • lymphocyte antigen 117
  • Synonym symbol(s) D6S49E,B144
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   HRE
    text structure DNA binding site
    MAPPING cloned Y linked N status confirmed
    Physical map
    HLA-B 6p21.3 major histocompatibility complex, class I, B MICA 6p21.3 MHC class I polypeptide-related sequence A HCP5 6p21.3 HLA complex P5 MICB 6p21.3 MHC class I polypeptide-related sequence B PPIP9 6p21.3 peptidylprolyl isomerase (cyclophilin) pseudogene 9 BAT1 6p21.33 HLA-B associated transcript 1 ATP6V1G2 6p21.3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 2 NFKBIL1 6p21.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 LTA 6p21.3 lymphotoxin alpha (TNF superfamily, member 1) TNF 6p21.3 tumor necrosis factor (TNF superfamily, member 2) LTB 6p21.3 lymphotoxin beta (TNF superfamily, member 3) LST1 6p21.3 leukocyte specific transcript 1 NCR3 6p21.3 natural cytotoxicity triggering receptor 3 AIF1 6p21.3 allograft inflammatory factor 1 BAT2 6p21.33 HLA-B associated transcript 2 BAT3 6p21.33 HLA-B associated transcript 3 APOM 6p21.31 apolipoprotein M C6orf47 6p21.3 chromosome 6 open reading frame 47 BAT4 6p21.33 HLA-B associated transcript 4 CSNK2B 6p21.3 casein kinase 2, beta polypeptide LY6G5B 6p21.3 lymphocyte antigen 6 complex, locus G5B LY6G5C 6p21.3 lymphocyte antigen 6 complex, locus G5C BAT5 6p21.33 HLA-B associated transcript 5 LY6G6D 6p21.3 lymphocyte antigen 6 complex, locus G6D LY6G6E 6p21.3 lymphocyte antigen 6 complex, locus G6E LY6G6C 6p21.3 lymphocyte antigen 6 complex, locus G6C C6orf25 6p21.3 chromosome 6 open reading frame 25 DDAH2 6p21.3 dimethylarginine dimethylaminohydrolase 2
    RNA
    TRANSCRIPTS type messenger
    text several alternatively spliced isoforms (I,S) (de Baey,Rollinger-Holzinjer)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1000 30 190 - -
    14
    - - - 640 - 97 - de Baey
    - - - 630 - 91 - de Baey
    - - 500 - 53 - de Baey
    - - 310 - 43 - Rollinger-Holzinjer
    - - 360 - 59 - Rollinger-Holzinjer
    - - 240 - 47 - Rollinger-Holzinjer
    - - 290 - 35 - Rollinger-Holzinjer
    - - 220 - 13 - Rollinger-Holzinjer
    - - 800 - - - Abraham
    - - 1200 - 117 - Nalabolu
    - splicing 500 - 53 - de Baey
    - splicing 640 - 97 - de Baey
    - splicing 630 - 91 - de Baey
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a 120AA extracellular region forming a V-type Ig-like domain with two potential N glycosylation sites
  • a 33aa cytoplasmic tail lacking an immunoreceptor tyrosine-based active motif (ITAM)
  • HOMOLOGY
    interspecies homolog to murine B144 transcript
    homolog to murine B144
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION interferon gamma inducible protein
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS