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FLASH GENE
Symbol LSP1 contributors: mct - updated : 27-08-2011
HGNC name lymphocyte-specific protein 1
HGNC id 6707
Location 11p15.5      Physical location : 1.874.199 - 1.913.492
Synonym name lymphocyte-specific protein pp52
Synonym symbol(s) WP34, pp52
DNA
TYPE functioning gene
STRUCTURE 39.29 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3929 - 339 - 2011 21030556
11 - 1842 - 277 - 2011 21030556
11 - 2072 - 277 - 2011 21030556
11 - 1578 - 277 - 2011 21030556
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel     Homo sapiens
Lymphoid/Immunelymph node    
 spleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow    Homo sapiens
Epithelialbarrier liningendothelium   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte Homo sapiens
Blood/Hematopoieticneutrophil Homo sapiens
Blood/Hematopoieticthymocyte
Cardiovascularendothelial cell Homo sapiens
Lymphoid/Immunelymphocyte Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal acidic domain with a casein kinase II site
  • a caldesmon domain
  • C terminal basic domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Lsp1
    Homologene
    FAMILY
    CATEGORY motor/contractile , unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text
  • expressed in the nucleus and cytosol of resting endothelial cells and associates with the cytoskeleton upon endothelial activation
  • basic FUNCTION
  • may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration
  • may be involved in transmembrane signal transduction through a postulated calcium- binding function
  • key regulator of transendothelial migration of neutrophils, modulating cell polarity and motility
  • complex function of LSP1 in regulating leukocyte recruitment to inflamed sites
  • important in leukocyte chemotaxis, and its absence promotes healing of skin wounds
  • F-actin-binding protein in the endothelium, that is critical for effective transmigration
  • endothelial LSP1 is recruited to the cytoskeleton in inflammation and plays an important role in forming endothelial domes thereby regulating neutrophil transendothelial migration, and playing a role in endothelial barrier integrity
  • play a pivotal role in leukocyte transmigration and microvascular permeability
  • plays an important role in leukocyte recruitment induced by both CXCL1 and CXCL2
  • endothelial LSP1 is critical in neutrophil adhesion and permeability elicited by CXCL1 but not CXCL2
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds actin
  • substrate of MAPKAPK2 in neutrophils (MAPKAPK2-regulated LSP1 phosphorylation is involved in stabilization of F-actin polarization during neutrophil chemotaxis)
  • endothelial LSP1 modulates extravascular neutrophil chemotaxis by regulating nonhematopoietic vascular PECAM1 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hairy cell leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lsp1(-/-) null mice showed accelerated healing of full-thickness skin wounds, with increased re-epithelialization rates, collagen synthesis, and angiogenesis
  • Lsp1-/- mice showed impaired neutrophil emigration paralleled by a disproportionate increase in vascular permeability after stimulation with TNF and CXCL1