SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton
|
text
| expressed in the nucleus and cytosol of resting endothelial cells and associates with the cytoskeleton upon endothelial activation |
basic FUNCTION
| may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration |
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may be involved in transmembrane signal transduction through a postulated calcium- binding function |
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key regulator of transendothelial migration of neutrophils, modulating cell polarity and motility |
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complex function of LSP1 in regulating leukocyte recruitment to inflamed sites |
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important in leukocyte chemotaxis, and its absence promotes healing of skin wounds |
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F-actin-binding protein in the endothelium, that is critical for effective transmigration |
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endothelial LSP1 is recruited to the cytoskeleton in inflammation and plays an important role in forming endothelial domes thereby regulating neutrophil transendothelial migration, and playing a role in endothelial barrier integrity |
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play a pivotal role in leukocyte transmigration and microvascular permeability |
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plays an important role in leukocyte recruitment induced by both CXCL1 and CXCL2 |
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endothelial LSP1 is critical in neutrophil adhesion and permeability elicited by CXCL1 but not CXCL2 |