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Symbol LSM4 contributors: mct - updated : 07-02-2011
HGNC name LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
HGNC id 17259
Location 19p13.11      Physical location : 18.417.717 - 18.434.001
Synonym name
  • glycine-rich protein
  • U6 snRNA-associated Sm-like protein LSm4
  • Synonym symbol(s) YER112W, GPR
    DNA
    TYPE functioning gene
    STRUCTURE 16.29 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    B3GNT3 19p13.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 INSL3 19p13.1-p12 insulin-like 3 (Leydig cell) JAK3 19p13.1 Janus kinase 3 (a protein tyrosine kinase, leukocyte) RPL18A 19p13 ribosomal protein L18a SLC5A5 19p13.2-p12 solute carrier family 5 (sodium iodide symporter), member 5 LOC115098 19p13.12 hypothetical protein BC013949 KCNN1 19p13.1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 CLONE24945 LOC284438 19p13.12 similar to Citrate synthase, mitochondrial precursor LOC126358 19p13.12 similar to apolipoprotein A-I binding protein; apoA-I binding protein LOC390897 19 similar to ribosomal protein S18 IL12RB1 19p13.1 interleukin 12 receptor, beta 1 KIAA0561 PIK3R2 19q13.2-q13.4 phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta) IFI30 19p13.1 interferon, gamma-inducible protein 30 MGC12972 19p13.11 hypothetical protein MGC12972 RAB3A 19p13.1 RAB3A, member RAS oncogene family PDE4C 19P13.1 phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) LOC388516 19 LOC388516 KIAA1683 19p13.1 KIAA1683 JUND 19p13.1 jun D proto-oncogene LSM4 19p13.1 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) PGPEP1 19p13.11 pyroglutamyl-peptidase I PLAB MGC10812 19p13.11 hypothetical protein MGC10812 LOC388517 19 similar to MOST-1 protein MAPA 19p13.11 monocyte and plasmacytoid activated molecule SSBP4 19p13.1 single stranded DNA binding protein 4 ISYNA1 19p13.11 myo-inositol 1-phosphate synthase A1 DKFZp434I1916 ELL 19p13.1 elongation factor RNA polymerase II FKBP8 19p12 FK506 binding protein 8, 38kDa MGC2749 19p13.11 hypothetical protein MGC2749 UBA52 19p13.1-p12 ubiquitin A-52 residue ribosomal protein fusion product 1 FLJ20850 19p13.11 hypothetical protein FLJ20850 CRLF1 19p12 cytokine receptor-like factor 1 C19orf4 19p12 chromosome 19 open reading frame 4 FLJ11078 19p13.11 hypothetical protein FLJ11078 MECT1 19p13 mucoepidermoid carcinoma translocated 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1167 - 139 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • SM sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop
  • HOMOLOGY
    Homologene
    FAMILY
  • SNRNP SM proteins family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text in isotonic conditions, associates with CLNS1A, and the plasma membrane
    basic FUNCTION
  • involved in mRNA splicing, nuclear mRNA splicing, via spliceosome
  • not only acts in RNA processing, but also as a co-factor in cell volume regulation
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLNS1A interaction partner (in isotonic conditions, LSM4 associates with CLNS1A and the plasma membrane)
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS