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FLASH GENE

Symbol

LSM4

contributors: mct - updated : 07-02-2011

HGNC name	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
HGNC id	17259

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.11      Physical location : 18.417.717 - 18.434.001
Synonym name	glycine-rich protein
	U6 snRNA-associated Sm-like protein LSm4
Synonym symbol(s)	YER112W, GPR

DNA

TYPE	functioning gene
STRUCTURE	16.29 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012321 5 - 1167 NP_036453 - 139 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

SM sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop

HOMOLOGY

Homologene

FAMILY

SNRNP SM proteins family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	in isotonic conditions, associates with CLNS1A, and the plasma membrane

basic FUNCTION	involved in mRNA splicing, nuclear mRNA splicing, via spliceosome
	not only acts in RNA processing, but also as a co-factor in cell volume regulation

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)

INTERACTION

DNA

RNA

small molecule

protein	CLNS1A interaction partner (in isotonic conditions, LSM4 associates with CLNS1A and the plasma membrane)
	PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS