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FLASH GENE
Symbol LSM1 contributors: mct - updated : 24-10-2016
HGNC name LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
HGNC id 20472
Location 8p12      Physical location : 38.020.860 - 38.034.026
Synonym name
  • cancer-associated SM-like protein
  • small nuclear ribonuclear CaSm
  • U6 snRNA-associated Sm-like protein LSm1
  • Synonym symbol(s) CASM, YJL124C
    DNA
    TYPE functioning gene
    STRUCTURE 13.17 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 935 - 133 - 2002 12515382
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestivestomach    
    Nervousbrain     Homo sapiens
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • SM sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop
  • HOMOLOGY
    Homologene
    FAMILY
  • SNRNP SM proteins family
  • CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • neuronal LSM1 is partially nuclear and inhibition of mRNA synthesis increases its nuclear localization
  • present in the dendrites
  • basic FUNCTION
  • its overexpression induced growth factor-independent proliferation
  • LSM1 and LSM8 act competitively with respect to the localization of the two complexes, suggesting a potential mechanism for co-regulation of nuclear and cytoplasmic RNA processing
  • deeply involved in prostate cancer progression through its downregulation, independent of any gene mutation
  • implicated in mRNA degradation in nonneuronal cells
  • with NCBP1, are translationally activated and contribute to the regulated local protein synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
  • component of the LSM1-7 complex involved in cytoplasmic mRNA degradation
  • EIF4E/EIF4ENIF1 complex is present in granules with the processing body proteins LSM1 and DDX6, and disruption of this complex causes premature and enhanced neurogenesis and neural precursor depletion
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LSM1-mRNPs contain the cap-binding protein NCBP1 that associates with (pre)mRNAs in the nucleus
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in multiple tumor types, including over 80 p100 of pancreatic tumors
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP rs16887244 SNP is located in intron 1 of LSM1, associated to schizophrenia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS