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FLASH GENE
Symbol LRRTM3 contributors: mct - updated : 21-12-2020
HGNC name leucine rich repeat transmembrane neuronal 3
HGNC id 19410
Location 10q21.3      Physical location : 68.685.791 - 68.860.867
Synonym symbol(s) MGC131810
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene, opposite orientation
text opposite orientation with CTNN3, in the intron 7 of CTNN3
STRUCTURE 175.08 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure located within the largest intron of CTNN3
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 5609 - 581 - 2016 26776509
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Nervousbrainlimbic systemhippocampus highly
 nerve   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • ten extracellular LRR domains flanked by cysteine-rich domains
  • a transmembrane region followed by an intracellular tail of 72 AA
  • HOMOLOGY
    Homologene
    FAMILY
  • LRRTM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    text LRRTM3 co-localizes with both APP and BACE1 in early endosomes, where BACE1 processing of APP occurs
    basic FUNCTION
  • having a role in the formation of the central nervous system and in maintenance and function
  • LRRTM1, LRRTM2, LRRTM3, LRRTM4 are postsynaptic adhesion molecules essential for excitatory synapse development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRTM3 controlled activity-regulated AMPA receptor surface expression in an alternative splicing-dependent manner
  • LRRTM3 and LRRTM4 have been found to be ligands for heparan sulfate proteoglycans, including glypican
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to late-onset Alzheimer disease (AD)
    Variant & Polymorphism other
  • genetic variation in LRRTM3 is associated with AD risk (
  • Candidate gene for late-onset Alzheimer disease
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lrrtm3-knockout mice displayed specific alterations in excitatory synapse density, excitatory synaptic transmission and excitability in DG granule neurons but not in CA1 pyramidal neurons