Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LRRTM2 contributors: shn - updated : 03-07-2010
HGNC name leucine rich repeat transmembrane neuronal 2
HGNC id 19409
Location 5q31.2      Physical location : 138.205.078 - 138.211.057
Synonym name
  • leucine-rich repeat neuronal 2 protein
  • leucine-rich repeat transmembrane neuronal 2 protein; leucine-rich repeat transmembrane neuronal protein 2
  • Synonym symbol(s) KIAA0416, FLJ76283, FLJ99831, LRRN2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text
  • CTNNA genes contain antisense oriented leucine rich repeat transmembrane (LRRTM) genes within their seventh introns (CTNNA1 containing LRRTM2)
  • STRUCTURE 5.93 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure located within the intron between exon 6 and 7 of CTNNA1
    MAPPING cloned Y linked N status provisional
    Map cen - D5S500 - D5S476 - LRRTM2 - D5S2009 - D5S2116 - qter
    Physical map
    NPY6R 5q31 neuropeptide Y receptor Y6 (pseudogene) TTID 5q31 titin immunoglobulin domain protein (myotilin) PKD2L2 5q31 polycystic kidney disease 2-like 2 C5orf5 5q31 chromosome 5 open reading frame 5 WNT8A 5q31 wingless-type MMTV integration site family, member 8A NME5 5q31.1 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) BRD8 5q31.2 bromodomain containing 8 KIF20A 5q31 kinesin family member 20A CDC23 5q31.1 CDC23 (cell division cycle 23, yeast, homolog) GFRA3 5q31.1-q31.3 GDNF family receptor alpha 3 CDC25C 5q31 cell division cycle 25C C5orf6 5q31 chromosome 5 open reading frame 6 C5orf7 5q31 chromosome 5 open reading frame 7 LOC51308 5q31 SGC32445 protein EGR1 5q31.1 early growth response 1 ETF1 5q31.1 eukaryotic translation termination factor 1 HSPA9B 5q31.1 heat shock 70kDa protein 9B (mortalin-2) LOC391836 5 similar to ribosomal protein L10a CTNNA1 5q31.1 catenin (cadherin-associated protein), alpha 1, 102kDa LRRTM2 5q31.3 catenin (cadherin-associated protein), alpha 1, 102kDa SIL1 5q31 endoplasmic reticulum chaperone SIL1, homolog of yeast MATR3 5q31.1-q31.3 matrin 3 PAIP2 5q31.1-q31.3 matrin 3 SLC23A1 20p13 solute carrier family 23 (nucleobase transporters), member 1 PACAP 5q23-5q31 proapoptotic caspase adaptor protein LOC389333 5 LOC389333 LOC389334 5 LOC389334 LOC202051 5q31.3 hypothetical protein LOC202051 MGC29463 5q31.3 hypothetical protein MGC29463 LOC340061 5q31.3 hypothetical protein LOC340061 UBE2D2 5q31.3 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) HSPC195 5q31.3 hypothetical protein HSPC195
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 5628 59 516 - 2003 12676565
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon lowly
     intestinesmall intestine  moderately
     liver   lowly
     stomach   moderately
    Endocrineadrenal gland   lowly
     pancreas   lowly
    Lymphoid/Immunespleen   moderately
     thymus   moderately
    Nervousbraindiencephalonhypothalamus  
     brainhindbraincerebellum predominantly
     braindiencephalonthalamus  
     brainforebraincerebral cortex  
     spinal cord   moderately
    Reproductivefemale systemplacenta  lowly
     female systemovary  lowly
     female systemuterus  lowly
     male systemprostate  moderately
     male systemtestis  lowly
    Respiratorylung   lowly
     respiratory tracttrachea  lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    nervouscerebellum
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • 21 leucine-rich (lrr) repeats
  • cysteione-rich domains
  • a transmembrane region
  • HOMOLOGY
    interspecies ortholog to LRRTM2, Pan troglodytes
    ortholog to Lrrtm2, Rattus norvegicus
    ortholog to Lrrtm2, Mus musculus
    Homologene
    FAMILY
  • LRRTM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    text localized postsynaptically
    basic FUNCTION
  • playing a role in development and maintenance of the central nervous system
  • promotes postsynaptic and by binding to specific splice variants of neurexin 1 presynaptic synapse assembly and plays a role in organization of the postsynaptic region
  • postsynaptic cell adhesion molecule that bind to presynaptic neurexins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neurexin 1 alapha and neurexin 1 beta
  • synaptic scaffolding protein PSD95 (also known as DLG4)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS