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FLASH GENE
Symbol LRRFIP2 contributors: mct - updated : 20-06-2012
HGNC name leucine rich repeat (in FLII) interacting protein 2
HGNC id 6703
Location 3p22.2      Physical location : 37.094.116 - 37.217.851
Synonym name LRR FLII-interacting protein 2
Synonym symbol(s) HUFI-2, DKFZp434H2035, FLJ20248, FLJ22683, FLJ58304
DNA
TYPE functioning gene
STRUCTURE 123.73 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
STAC 3p22.3 src homology three (SH3) and cysteine rich domain LOC205655 3p22.1 similar to hypothetical protein MGC8902 KIAA1765 3p22.1 KIAA1765 protein KIAA0342 3p24.2-p23 KIAA1765 protein LOC389106 3 LOC389106 LOC389107 3 similar to Hsp70/Hsp90 organizing protein homolog CG2720-PA LOC389108 3 LOC389108 LOC391527 3 similar to chromosome 2 open reading frame 7 EPM2AIP1 3p22.1 EPM2A (laforin) interacting protein 1 MLH1 3p21.3 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) LRRFIP2 3p24.3-p23 leucine rich repeat (in FLII) interacting protein 2 FLJ31715 3p22.1 hypothetical protein FLJ31715 GOLGA4 3p22-p21.3 golgi autoantigen, golgin subfamily a, 4 APRG1 3p22.1 AP20 region protein ITGA9 3p21.3 integrin, alpha 9 CTDSPL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like VILL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like PLCD1 3p21.3 phospholipase C, delta 1 DLEC1 ACAA1 3p23-p22 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) MYD88 3p22-p21.3 myeloid differentiation primary response gene (88)
RNA
TRANSCRIPTS type messenger
text specific alternatively spliced transcripts 3.9 and 2.8kb expressed in heart and skeletal muscle (Fong)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 3826 82.2 721 - -
15 - 2935 - 424 - -
14 - 2863 - 400 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled motifs interacting with the LRR domain of FLI
  • HOMOLOGY
    Homologene
    FAMILY
  • LRRFIP family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • by promoting the translocation of LRRFIP2 into cytoplasmic aggregates, UBD might block its recruitment to the membrane and its subsequent role in NFKB1 activation through TLR4 stimulation
  • basic FUNCTION
  • plays an important role in transducing Wnt signals
  • positively regulate cytokine production in macrophages, suggesting a functional role in TLR4-mediated inflammatory response
  • positively regulates NFKB and macrophage cytokine production after lipopolysaccharide
  • signal regulator, that modulates the time course-dependent changes in NFKB activity through its dynamic interaction with the TLR adaptor protein, MYD88
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FLI binding
  • interacts with DVL3 to increase the cellular levels of beta-catenin and activate beta-catenin/LEF/TCF-dependent transcriptional activity
  • MYD88 interacting with LRRFIP2 and LRRFIP1, and both are positive regulators of NF-kappaB activity
  • binds to MYD88 through its serine-rich domain (phosphorylation at serine 202 was found to regulate the dynamics of the LRRFIP2-MYD88 interaction, which in turn modulated the strength and duration of TLR4 signaling)
  • LRRFIP2 is involved in NFKB1 activation following stimulation of TLR4
  • LRRFIP2 and TOR1AIP2 are FATylation substrates
  • LRRFIP2 enhances the interaction between FLII and CASP1, facilitating the inhibitory effect of FLII on CASP1 activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    deletion, comprising exons 17-19 of the MLH1 gene and exons 26-29 of the LRRFIP2 gene in Lynch syndrome in
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS