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FLASH GENE
Symbol LRRC8B contributors: - updated : 05-12-2005
HGNC name leucine rich repeat containing 8 family, member B
HGNC id 30692
Location 1p22.2      Physical location : 89.990.396 - 90.063.418
Synonym name T-cell activation leucine repeat-rich protein
Synonym symbol(s) KIAA0231, MGC42220, TA-LRRP
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 35.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 16 extracellular leucine-rich repeats
  • four trahnsmembrane regions
  • HOMOLOGY
    Homologene
    FAMILY LRRC8 family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be implicated in proliferation and activation of lymphocytes and monocytes
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS