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FLASH GENE
Symbol LRRC70 contributors: mct - updated : 02-02-2013
HGNC name leucine rich repeat containing 70
HGNC id 35155
Location 5q12.1      Physical location : 61.874.561 - 61.877.275
Genatlas name synleurin
Synonym symbol(s) UNQ1891, SLRN
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text in tandem with IPO11, KIF2A
STRUCTURE 2.71 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2290 70.3 622 - 2003 12767927
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   moderately Homo sapiensAdult
Lymphoid/Immunespleen   moderately Homo sapiensAdult
Nervous    moderately Homo sapiensAdult
Reproductivefemale systemuterus  moderately Homo sapiensAdult
 male systemtestis  moderately Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately Homo sapiensAdult
Connectivecartilage  moderately Homo sapiensAdult
Muscularsmooth  moderately Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • major part of the extracellular domain consists of a leucine-rich repeats (LRR) cassette with a LRR central core having 12 analogous LRR repeating modules arranged in a seamless tandem array
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • leucine-rich repeat protein, that renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS)
  • having synergistic effect on cytokine stimulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS