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FLASH GENE
Symbol LRRC7 contributors: mct - updated : 16-04-2005
HGNC name leucine rich repeat containing 7
HGNC id 18531
Location 1p31.1      Physical location : 70.225.857 - 70.589.169
Synonym name
  • densin
  • densin-180
  • protein LAP1
  • Synonym symbol(s) KIAA1365, MGC144918, DKFZp686I1147, LAP1
    DNA
    TYPE functioning gene
    STRUCTURE 363.31 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 996 - 216 brain-specific Wang (2003)
  • also called densin-180
  • a nuclear localization signal and four leucine-rich repeats (LRRs)
  • 25 splicing 6313 172.45 1537 ubiquitous Ahola (2003)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Urinarykidneynephron   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear localization signal
  • 20 leucine-rich (LRR) repeats
  • HOMOLOGY
    Homologene
    FAMILY
  • O-sialoglycoprotein family
  • LAP (LRR and PDZ) protein family
  • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • functioning in specific adhesion between presynaptic and postsynaptic membrane at glutamatergic synapses
  • involved in the synaptic organization, maintenance of cell shape and polarity in nerve cells and in podocytes having a role by associating with the nephrin interacting protein complex at the slit diaphragm
  • molecule shared by the kidney glomerular podocytes and pancreatic islet cells (Rinta-Valkama 2007)
  • with KIRREL2 can act as autoantigens, and autoantibodies against these can be detected in patients with type 1 diabetes (Rinta-Valkama 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS