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FLASH GENE
Symbol LRRC59 contributors: mct - updated : 12-04-2016
HGNC name leucine rich repeat containing 59
HGNC id 28817
Location 17q21.33      Physical location : 48.458.593 - 48.474.914
Synonym name
  • ribosome-binding protein p34
  • Synonym symbol(s) PRO1855, p34, FLJ21675
    DNA
    TYPE functioning gene
    STRUCTURE 16.32 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2933 - 307 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NLS-like sequences in its cytosolic part that can mediate nuclear import of soluble LRRC59 variants
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    text
  • membrane-anchored protein that localizes to the endoplasmic reticulum (ER) and the nuclear envelope (NE)
  • basic FUNCTION
  • facilitates transport of cytosolic FGF1 through nuclear pores by interaction with KPNA1, KPNB1 and movement of LRRC59 along the ER and NE membranes
  • ER membrane protein, participated in trafficking of nucleic acid (NA)-sensing TLRs from the ER
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC59 was identified as an intracellular binding partner of FGF1, and LRRC59 is strictly required for nuclear import of exogenous FGF1
  • CIP2A is translocated into the nucleus at G2/M through its association with LRRC59
  • upon ligand stimulation, LRRC59 associated with UNC93B1 in a TLR-independent manner, which required signals induced by ligand internalization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS