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FLASH GENE

Symbol

LRRC56

contributors: mct - updated : 27-11-2018

HGNC name	leucine rich repeat containing 56
HGNC id	25430

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ICS41 immotile cilia syndrome 41
Location	11p15.5      Physical location : 537.521 - 554.915
Synonym symbol(s)	FLJ00101, DKFZp761L1518

DNA

TYPE	functioning gene
STRUCTURE	35.95 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198075 14 - 2765 NP_932341 - 542 - 2018 30388400

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung       highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Respiratory ciliari cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

five leucine-rich repeat domains conserved across species whose motile cilia are assembled by intraflagellar transport (IFT)

HOMOLOGY

interspecies

homolog to Chlamydomonas Oda8

Homologene

FAMILY

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	is recruited to the cilium during axoneme construction, where it co-localizes with IFT trains and is required for the addition of dynein arms to the distal end of the flagellum

basic FUNCTION	play likely a role in intraflagellar transport (IFT)-dependent assembly of outer row dynein arms, not axonemal docking
	plays likely an important role in formation and transport of mature dynein complexes during flagellar assembly
	having a likely role in dynein transport during cilia assembly that is evolutionarily important for cilia motility
	recruited during flagellar assembly before its removal during flagellum maturation, after cell division
	likely performs an IFT-associated function in motile cilia
	potential role for LRRC56 in the assembly of dynein arms in the distal portion of the axoneme

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

LRRC56 interacts with the intraflagellar transport (IFT) protein IFT88

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ICS41

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS