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FLASH GENE
Symbol LRRC4B contributors: mct - updated : 31-10-2013
HGNC name leucine rich repeat containing 4B
HGNC id 25042
Location 19q13.33      Physical location : 51.020.151 - 51.071.302
Synonym name
  • leucine-rich repeats and immunoglobulin-like domains 4
  • netrin-G3 ligand
  • Synonym symbol(s) HSM, LRIG4, NGL-3
    DNA
    TYPE
    STRUCTURE 51.15 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2958 - 713 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY superfamily of leucine-rich repeat (LRR) proteins
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text
  • LRRC4, LRRC4B, LRRC4C are mainly localized to the postsynaptic side of excitatory synapses
  • basic FUNCTION
  • regulate axonal outgrowth and lamina-specific dendritic segmentation, suggesting that the NGL-dependent adhesion system is important for the development of axons, dendrites, and synapses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the presynaptic ligands LAR
  • interact with the abundant postsynaptic density (PSD) protein, DLG4, and other postsynaptic proteins, including NMDA receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS