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FLASH GENE
Symbol LRRC3B contributors: mct - updated : 28-03-2011
HGNC name leucine rich repeat containing 3B
HGNC id 28105
Location 3p24.1      Physical location : 26.664.299 - 26.752.263
Synonym name
  • leucine-rich repeat protein LRP15
    • Synonym symbol(s) UNQ195/PRO221, LRP15, MGC102927
    DNA
    TYPE functioning gene
    STRUCTURE 87.97 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1718 - 259 - 2008 18377727
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • might be regulated by DNA methylation and had an important role in DNA repair
  • confers resistance to UV damage and accelerates the DNA repair rate
  • putative tumor suppressor silenced in gastric cancers by epigenetic mechanisms and its silencing in cancer may play an important role in tumor escape from immune surveillance
  • may be a novel methylation-sensitive tumor suppressor gene in CRC (colorectal cancer)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    methylation intensity was significantly higher in colorectal cancer tissues than in the corresponding non-cancerous tissues
    tumoral     --low  
    by hypermethylation (promoter region of LRRC3B was aberrantly methylated) in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS