basic FUNCTION
| modulates the gating of KCNMA1 by enhancing the allosteric coupling between voltage-sensor activation and the channel closed–open transition |
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role in the suppression of tumor growth and metastasis may be through its alteration of the tumor microenvironment |
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LRRC52 and LRRC26 define a new family of auxiliary subunits capable of critically modifying the gating behavior of Slo family channels |
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LRRC52, LRRC55, and LRRC38 potentially function as LRRC26-type auxiliary subunits of BK channels |
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LRRC26 and its paralogs are structurally and functionally distinct from the beta-subunits and are a gamma family of the BK channel auxiliary proteins, which potentially regulate the channel gating properties over a spectrum of different tissues or cell types |