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FLASH GENE
Symbol LRRC25 contributors: np/ - updated : 02-03-2005
HGNC name leucine rich repeat containing 25
HGNC id 29806
Location 19p13.11      Physical location : 18.501.954 - 18.508.415
Synonym name monocyte and plasmacytoid activated molecule
Synonym symbol(s) MAPA, FLJ38116
DNA
TYPE functioning gene
STRUCTURE 6.46 kb     2 Exon(s)
regulatory sequence
motif repetitive sequence   ALU
text structure Intron 2 containing Alu-type repeats, and exon 2 encodes both the extracellular domain and the transmembrane region
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2430 - 305 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticgranulocyte
Blood/Hematopoieticmonocyte
Lymphoid/Immuneactivated B lymphocyte
Lymphoid/Immunedendritic cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a transmembrane domain
  • four leucine-rich repeats, which are often associated with protein-protein interactions
  • a cysteine-rich region
  • two tyrosine-based motifs, one for interaction with phosphatidylinositol-3 kinase and the other an immunoreceptor tyrosine-based activation motif (ITAM)
  • a cytosolic C terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be involved in the activation of cells of innate and acquired immunity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS