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FLASH GENE
Symbol LRRC19 contributors: mct - updated : 22-01-2010
HGNC name leucine rich repeat containing 19
HGNC id 23379
Location 9p21.2      Physical location : 26.993.142 - 27.005.691
Synonym symbol(s) FLJ21302
DNA
TYPE functioning gene
STRUCTURE 12.55 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3624 - 370 - 2009 19679103
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon   Homo sapiens
Lymphoid/Immunespleen   highly Homo sapiens
Urinarykidney   predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four leucine-rich repeats, which were numbered sequentially and arranged in tandem array in the extracellular domain (Chai 2009)
  • a putative protein kinase casein kinase2 (CK2) phosphorylation site
  • single-span transmembrane domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • leucine-rich repeat protein family
  • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • able to activate NF-kappaB and induce production of proinflammatory cytokines
  • may play an important role in inducing innate immune responses in certain tissues such as the kidney
  • may be involved in the response to certain pathogenic microorganisms that cause infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS