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FLASH GENE
Symbol LRRC15 contributors: - updated : 21-04-2004
HGNC name leucine rich repeat containing 15
HGNC id 20818
Location 3q29      Physical location : 194.075.976 - 194.090.472
Synonym name leucine-rich repeat protein induced by beta amyloid
Synonym symbol(s) LIB
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC151963 3q29 similar to BcDNA:GH11415 gene product LOC285388 3q29 similar to vascular endothelial zinc finger 1 HRASLS 3q28-q29 HRAS-like suppressor DKFZp761I1011 3q29 hypothetical protein DKFZp761I1011 OPA1 3q28-q29 optic atrophy 1 (autosomal dominant) LOC389186 3 LOC389186 HES1 3q28-q29 hairy and enhancer of split 1, (Drosophila) LOC254808 3q29 hypothetical protein LOC254808 LOC285280 3q29 similar to Carboxypeptidase N 83 kDa chain (Carboxypeptidase N regulatory subunit) LRRC15 3q29 leucine rich repeat containing 15 GP5 3q29 glycoprotein V (platelet) AFURS1 3q29 ATPase family homolog up-regulated in senescence cells LOC391605 3 similar to 60S ribosomal protein L23a LOC93109 3q29 hypothetical protein BC007772 FLJ11301 3q29 hypothetical protein FLJ11301 FLJ90022 3q29 hypothetical protein FLJ90022 LOC285303 3q29 similar to MGC27169 protein FLJ35155 3q29 hypothetical protein FLJ35155 CENTB2 3q29 centaurin, beta 2 PPP1R2 3q29 protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC391606 3 similar to ribosomal protein L24 LOC255812 3q29 hypothetical protein LOC255812 LOC389187 3 LOC389187 MUC20 3q29 mucin 20 MUC4 3q29 mucin 4, tracheobronchial LOC285253 3q29 similar to SPBPJ4664.02 ACK1 3q29 activated Cdc42-associated kinase 1 LOC391607 3 hypothetical gene supported by AJ271448; NM_174907 LOC375386 3q29 similar to Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (Fp) (Flavoprotein subunit of complex II) LOC391608 3 hypothetical gene supported by AJ271448; NM_174907 TFRC 3q29 transferrin receptor (p90, CD71) ZDHHC19 3q29 zinc finger, DHHC domain containing 19 OSTalpha 3q29 organic solute transporter alpha PCYT1A 3q21-q28 phosphate cytidylyltransferase 1, choline, alpha isoform MGC33212 3q29 hypothetical protein MGC33212 LOC116211 3q29 hypothetical protein BC013113
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines breast carcinoma
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta, invasive cytotrophoblast layer
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
15 leucine-rich repeats
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY LRR superfamily
CATEGORY receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
text present at theb leadig edge of migrating cells
basic FUNCTION may play a role in cellular invasion
promoting glial migration through extracekkular matrix
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling signal transduction
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other induced in snile plaque-associated astrocytes
REGULATION
induced by EWS-WT1 (+KTS) in the tumor DSRCT, contributing to the invasive phenotype
ASSOCIATED DISORDERS
ANIMAL & CELL MODELS