SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| text
| colocalizing with cubilin (CUBN) in the kidney proximal tubule |
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apical membrane |
| basic FUNCTION
| multifunctional clearance receptor, with endocytic function, endocytic receptor on the apical membranes of proximal tubule cells (PTC) in the kidney, and is involved in the reabsorption and metabolism of various proteins |
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possessing broad ligand specificity and mediating the uptake and lysosomal degradation of macromolecules |
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including lipoproteins, proteases and protease inhibitors and in vivo the Ca2+ sensing in the parathyroids, renal uptake of 25 (OH) D3 and activation of CYP25D1A, of renal uptake of retinol bound to RBP |
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acting as a new regulatory component of the SHH signaling pathway |
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endocytic receptor on the apical membranes of proximal tubule cells, involved in the reabsorption of albumin(essential process for overall body homeostasis) |
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large, multiligand endocytic receptor and member of the low-density lipoprotein-receptor family, able to bind and mediate cellular uptake of folate binding proteins |
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promoting both the protection of normally functioning cells at low/physiological albumin concentrations and programmed cell death at high concentrations more typical of disease states |
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mediating SEPP1 uptake by the kidney proximal tubule, a tissue requiring a high selenium supply to support synthesis of GPX3 |
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receptor for albumin in astrocytes and is required for the synthesis of the neurotrophic factor oleic acid  |
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with CUBN, are multifunctional endocytotic receptors expressed in many absorptive epithelia |
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plays a critical role in the endocytosis of albumin and other filtered low-molecular-weight proteins |
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plays a critical role in the reabsorption (endocytosis) of glomerular-filtered proteins including albumin and low-molecular-weight proteins |
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potentially prevents urinary SEPP1 loss and participates in brain Se/SePP1 uptake |
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has an important role in Abeta-mediated neurotoxicity, and therefore may be involved in the neurodegenerative processes that occur in Alzheimer disease |
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LRP8, and LRP2 mediate tissue-specific SEPP1 uptake |
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prevents urinary SEPP1 loss and participates in brain Selenium/SEPP1 uptake |
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LRP2 recycles from the endocytic recycling compartment (ERC) back to the plasma membrane (PM) via the slow recycling pathway |
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LRP2 and CUBN may be important in human maternal-fetal transfer, and they increase across gestation to facilitate this function |
